Journal of Pediatric Neurology and Neuroscience

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Journal of Pediatric Neurology and Neuroscience Archives

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Case Report   |   10.36959/595/444 Volume 6 Issue 1

Reversible Cerebral Vasoconstriction Syndrome following Exchange Transfusion and Steroids in a Child with Sickle Cell Disease: A Case Report

Authors: Matthew A Tester, BSc, Maksim Parfyonov, MD, FRCPC, Paul Webb, MD, FRCPC and Anita N Datta, MD, FRCPC
Reversible cerebral vasoconstriction syndrome (RCVS) is clinical and radiographic entity with several identified triggers, characterized by severe headaches and a reversible “string of beads” appe... Read more

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Case Report   |   10.36959/595/443 Volume 6 Issue 1

Unusual Diagnosis and Extended Management of Chronic Inflammatory Demyelinating Polyneuropathy in an Unimmunized Patient

Authors: Victoria Danan, BA, Sabina Fridman, BS, Christine Lopez, DO and Areeba Basit, MD
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is a rare autoimmune disorder, often of idiopathic cause, but one that can result as a complication of Guillain Barre Syndrome (GBS). It often ... Read more

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Case Report   |   10.36959/595/442 Volume 6 Issue 1

Treatment of Bi-Allelic PRRT-2 Mutation Associated Ataxia and Paroxysmal Dyskinesia

Authors: Naini Shiswawala, BA and Sumit Parikh, MD
PRRT2 is located on chromosome 16p11.2 and is a transmembrane protein highly expressed in the CNS that has been identified to play a role in epilepsy, movement disorders and hemiplegic migraines. Spec... Read more

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Case Report   |   10.36959/595/441 Volume 6 Issue 1

Treatment of COVID Encephalitis in Pediatric Patient with IVIG

Authors: Joseph Collins, MD and Ali Jamal, MD
We herein report a case of encephalitis in a pediatric patient with SARS-COVID-19 infection. The diagnosis is discussed consisting of physical exam, electroencephalogram, lumbar puncture, and MRI brai... Read more

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Case Report   |   10.36959/595/440 Volume 6 Issue 1

It's a Bit Crowded in Here: Examining Pressure Reactivity in Craniocerebral Disproportion

Authors: Kristine Elizabeth Woodward, MD,MSc, Michael Joachim Esser, MD,PhD and Clare Naomi Gallagher, MD,PhD
Pressure reactivity index (PRx) is a measure used to gain insights into cerebrovascular reactivity. It is generally used in acute settings such as traumatic brain injury and subarachnoid hemorrhage, h... Read more

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Case Report   |   10.36959/595/439 Volume 6 Issue 1

A Novel PPP2CA Gene Variant Presenting with Dystonia and Progressive Brain Atrophy

Authors: Cheng E, Cobben J and Ismayilova N
PPP2CA gene mutations are rare and associated with a neurodevelopmental disorder with or without structural brain abnormalities. We present a case of a novel de novo PPP2CA gene mutation, namely c.176... Read more

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Original Article   |   10.36959/595/438 Volume 5 Issue 1

Focal Electrographic Hints in Epileptic Spasms

Authors: Mahmoud Mohammadi MD, Reza Shervin Badv, MD, Bahram Yarali, Safoura Kowkabi, Mahmoud Reza Ashrafi, Gholam Reza Zamani, Ali Reza Tavasoli, Mohsen Javadzadeh, Morteza Heidari, Mostafa Ghorbani and Zahra Rezaei MD
Epileptic spasms (ES) is an age specific seizure disorder which is more frequent in infancy. Frequent untreated epileptic events have negative effect on development in ES patients so early diagnosis a... Read more

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Case Report   |   10.36959/595/437 Volume 5 Issue 2

Transverse Myelitis Secondary to SARS-CoV-2 Infection in a Pediatric Patient

Authors: Luis Del Carpio-Orantes, Bernardo Ramírez-Orantes, Carlos Humberto Aguilar-Arguello, Gonzalo Antonio Neme Díaz and Pablo Valladares-Sánchez
The clinical case of an 11-year-old male patients presented, treated at the Internal Medicine Service of the Hospital Regional de Alta Especialidad del Niño Dr. Rodolfo Nieto Padrón, Tabasco for pre... Read more

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Research Article   |   10.36959/595/436 Volume 5 Issue 2

Febrile Coronavirus and Autism

Authors: Gary Steinman and David Mankuta
A number of reports have pointed to the apparent relationship between reduced IGF1 in pregnancies and the development of autism in the offspring. Fever due to inflammatory processes in the gravida eme... Read more

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Case Report   |   10.36959/595/435 Volume 5 Issue 2

CD59 Deficiency in Two Bahraini Children: Clinical Profile and Outcome

Authors: Ayman Khalil Ali and Fatema Naser Alfayez
CD59 is an inherited autosomal recessive disorder characterized by various clinical manifestations including hemolytic anemia, neurological deficit due to recurrent stroke and chronic inflammatory dem... Read more

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Case Report   |   10.36959/595/433 Volume 5 Issue 2

Posterior Reversible Encephalopathy Syndrome in a Pediatric Patient with SARS-CoV-2 Infection

Authors: Anita Mathew, DO, Richard Sultan, DO and Zelda J Ghersin, MD
Posterior reversible encephalopathy syndrome (PRES) is a clinical syndrome associated with certain underlying conditions or medications, with a spectrum of neurologic findings and characteristic neuro... Read more

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Case Report   |   10.36959/595/432 Volume 5 Issue 2

Pediatric Spinal Cord Injury without Neuroimaging Abnormality (SCIWNA): A Clinico-Radiological Conundrum

Authors: Kamer Singh Rana, MD (Paed), Jyotindra Narayan Goswami, MD (Paed), DNB (Paed), DM (Paed Neurology), MNAMS and Dinesh Sareen, MD (Internal Medicine), DM (Neurology)
‘Spinal Cord Injury Without Neuroimaging Abnormality’ (SCIWNA) is a clinico-radiological entity characterized by clinical markers of traumatic myelopathy without neuroimaging evidence of spinal in... Read more

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Case Report   |   10.36959/595/431 Volume 5 Issue 2

Intracranial and Ocular Abnormalities in a Child with Neurodevelopmental Delay

Authors: Meghna Rajaprakash, MSc, MD, Jessica Heymans, BA and Erick Sell, MD
A patient with neurodevelopmental delay and an unremarkable prenatal and birth history presented postnatally with congenital cataracts and neuroanatomical abnormalities including periventricular calci... Read more

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Research Article   |   10.36959/595/430 Volume 5 Issue 2

Childhood Epileptic Encephalopathy in Sokoto, Northwestern Nigeria

Authors: MM Ahmad and H Ahmed
Pediatric epileptic encephalopathies comprises a group of severe childhood epilepsy syndromes characterized by refractory seizures associated with progressive cerebral dysfunction, manifesting as cogn... Read more

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Research Article   |   10.36959/595/429 Volume 5 Issue 2

Prevalence and Patterns of Psychosocial Problems among Adolescents with Epilepsy in Enugu, Nigeria: A Cross-Sectional Study

Authors: Chukwubike Onyebuchi Nnajekwu, MBBS, FMC Paed, Uchenna Chiagoziem Nnajekwu, MBBS, FMC Paed, Anthony Nnaemeka Ikefuna, MBBS, FMC Paed, FRCP and Ngozi Chinyelu Ojinnaka, MBBS, FWACP, MPH
The prevalence of psychosocial problems was significantly higher in the adolescents with epilepsy compared to the apparently healthy controls. Externalising problems were the most common pattern obser... Read more

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Short Report   |   10.36959/595/428 Volume 5 Issue 2

Antenatal Counselling in Developmental Delay and Intellectual Disability: Case Series

Authors: Reema Bhatt, MD(Pediatrics), DNB (Pediatrics), DM(Pediatric Neurology), MNAMS, Ratna Dua Puri, MD(Pediatrics), DM(Medical Genetics), and Jyotindra Narayan Goswami, MD(Pediatrics), DNB(Pediatrics), DM (Pediatric Neurology), MNAMS
Intellectual disability and developmental delay are common presentations encountered in pediatric clinical practice. The etiologies of these illnesses are diverse. Subtle clinical markers may act as p... Read more

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Case Report   |   10.36959/595/427 Volume 5 Issue 2

Guillain-Barré Syndrome Triggered by COVID-19: A Pediatric Case Report and Literature Review

Authors: Anthony Declusin, MD, Laura Bricklin, MD, Melisa Tanverdi, MD, Andrew White, MD, Michelle Brajcich, MD, John Szigety, MD, Lauren DiSalvo, DO, Nicholas Breitnauer, MD, Nicholas Stence, MD, William Mundo, MPH, and Padmini Palat, MD, MPH
Coronavirus disease 2019 (COVID-19) has been associated with a variety of neurologic manifestations, including Guillain- Barré syndrome (GBS), but few pediatric cases have been reported. We would lik... Read more

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Case Report   |   10.36959/595/426 Volume 5 Issue 2

Posterior Reversible Encephalopathy Syndrome Caused by Autonomic Dysreflexia in an Adolescent after Spinal Cord Injury

Authors: Javid Sardarzada, Sibel Öz, Dilara Mat, İbrahim Öncel, Ali Düzova and Banu Anlar
The posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological entity caused by impairment of cerebral autoregulation leading to vasogenic edema. Common etiologies include immunosup... Read more

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Case Report   |   10.36959/595/425 Volume 5 Issue 2

Reversible MRI Changes in the Splenium Related to Recent Cessation of Antiepileptic Medications

Authors: McLaren J, Misra A and Chu CJ
A 21-year-old male with history of refractory epilepsy presented for long-term video EEG monitoring. His home antiepileptic medications were weaned off over a seven-day period. On hospital day 4, he h... Read more

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Case Report   |   10.36959/595/424 Volume 5 Issue 2

Reversible Signal Abnormalities in Bilateral Dentate Nuclei Secondary to Isoniazid Neurotoxicity

Authors: CaragherS, McLaren J and Balaban D
An 11-year-old Colombian female on isoniazid for recently diagnosed latent tuberculosis presented to the emergency department after a first-time, generalized tonicclonic seizure. She exhibited mild bi... Read more

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Letter to Editor   |   10.36959/595/423 Volume 5 Issue 2

Tourette Syndrome Mimic: An Atypical Presentation of Subacute Sclerosing Panencephalitis

Authors: Sandeep Paimode, MD and Jyotindra Narayan Goswami, MD, DNB, DM, MNAMS
A 10.5-year-old girl presented with abnormal movements and behavioural problems for three months. Initially she used to have lip-twitching and eye-blinking when awake. After six weeks, she started hav... Read more

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Case Report   |   10.36959/595/422 Volume 5 Issue 2

Encephalopathy and Cytotoxic Lesion of the Corpus Callosum Associated with Cytokine Storm in COVID-19: A Case Report

Authors: Duyu A Nie, MD, PhD
The neurological complications and neuroradiological spectrum of the SARS-CoV-2 infection (COVID-19 disease) in pediatric patients are increasingly recognized, however, the pathophysiology of the cent... Read more

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Original Article   |   10.36959/595/421 Volume 5 Issue 1

Growing Skull Fracture [GSF], a Hydrodynamic Perspective: An Original Article

Authors: Allan J Drapkin, MD, FACS(R)
Growing skull fracture (GSF) is a well-known complication of pediatric cranial trauma but its physiopathology has been, so far, only assumed. When the basic laws of hydraulics are applied to the under... Read more

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Case Report   |   10.36959/595/420 Volume 5 Issue 1

Spontaneous Intracranial Hypotension Presenting with Chiari Malformation and Hydrocephalus Associated With Lumbar Pseudoarachnoiditis

Authors: Lacey M Carter, MD and Naina L Gross, MD
Spontaneous intracranial hypotension (SIH) is a rare occurrence, especially in children. In the pediatric population, three cases of Chiari malformation in children and no cases of hydrocephalus due t... Read more

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Case Report   |   10.36959/595/419 Volume 5 Issue 1

Mixed Nervous System Involvement in a Child with Multisystem Inflammatory Syndrome- A Rare Presentation of SARS-CoV-2

Authors: Aysha Fakhroo, Naveen Divakaran, Fareedul Hassan, Gabriel Fox, Imelda Lambert and Ahood Almuslamani
Multi-system inflammatory syndrome (MIS-C) is a rare but severe complication of Covid-19 infection. The clinical presentation ranges from a mild course of systemic inflammatory response to a life thre... Read more

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Research Article   |   10.36959/595/418 Volume 5 Issue 1

Abusive Head Trauma in Infants and Children: Identifying Presenting Variables Associated With Outcome

Authors: Jessica L Carpenter, MD, Raquel Farias-Moeller, MD, Amy H Jones, MD, Shan Lateef, Abigail Ley, MD and Allison Jackson, MD, MPH
We review 52 cases of presumed abusive head trauma (AHT) in children < 24 months of age admitted to a single center Pediatric Intensive Care Unit (PICU) between 2008 and 2017. Clinical variables were ... Read more

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Review Article   |   10.36959/595/417 Volume 5 Issue 1

Hypothermia as an Adjunctive Treatment in Pediatric Patients with Naegleria fowleri: A Systematic Review

Authors: Archie Defillo, MD, Penelope E Nussbaum, Parvathy Hariharan, MS, Alexander Mebane, BS and Eric S Nussbaum, MD
We reviewed the literature for pediatric patients infected with Naegleria fowleri (N. fowleri) to assess the relationship between patient survival and treatment with hypothermia. A systematic literatu... Read more

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Case Report   |   10.36959/595/416 Volume 5 Issue 1

Intracranial Mass Lesion Caused by Inflammatory Pseudotumor: A Case Report and Discussion

Authors: Andrew Reisner, MD, Matthew Schniederjan, MD, Joshua J Chern, MD, PhD, Andrew Appert, BS, Hannah E. Myers, BS. Psych, Barunashish Brahma, MD, Laura S Blackwell, PhD, William R Boydston, MD, PhD, and Sampath Prahalad, MD
Inflammatory pseudo tumors are uncommon lesions that may, on occasion, occupy the intracranial space. Their management is unstandardized. We present a case of skull-based inflammatory pseudotumor in a... Read more

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Case Series   |   10.36959/595/415 Volume 5 Issue 1

Benign Neonatal Sleep Myoclonus in Uyo: Presentations, Diagnosis and Outcome

Authors: Eno Etim Nyong, MBBS, FWACP*, Mkpouto Udeme Akpan, MBBS, FWACP, Paulinus Umoren Essien, MBBS, FWACP and Itoro Anietimfon Akpan, MBBS, FWACP
To describe four neonates with jerky movements of the limbs who were seen in University of Uyo Teaching Hospital between January 2014 to December 2018. They were all referred from other facilities for... Read more

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Clinical Trial   |   10.36959/595/414 Volume 5 Issue 1

Modified Atkins Diet for Tics Requiring Treatment in Tourette Syndrome: A Randomized Controlled Trial of Early Versus Late Initiation

Authors: Camilla B Sørensen, MD, Liselotte Skov, MD, MSc, Lone Aaslet, NP, Helle Nielsen, RD, Mette Mortensen, RD, Theis Lange, PhD, Nanette Mol Debes, MD, PhD and Maria J Miranda, MD, PhD
Increased dopamine activity is thought to play a role in the pathophysiology of Tourette syndrome (TS). Since ketogenic diet (KD) is thought to change several neurotransmitter systems, we hypothesized... Read more

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Research Article   |   10.36959/595/413 Volume 5 Issue 1

How did Children with Complex Care Needs Affect during the Lockdown Due to the COVID-19 Pandemic?

Authors: V Mundada, T Gupta, A Pamfilo, A Joseph and S Banu
The COVID-19 pandemic and the lockdown imposed by most of the governments because of it have affected most of us including children with complex care needs. Because of various reasons like changed rou... Read more

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Case Report   |   10.36959/595/412 Volume 4 Issue 1

Kabuki Syndrome: A Rare Genetic Multisystem Disorder in Bangladesh

Authors: Zeena Salwa, Md Masudur Rahman and AT Nizam Uddin Ahmed
Purpose of reporting the case of a Bangladeshi female child diagnosed as Kabuki syndrome with all her clinical features, laboratory tests and genetic report. This case highlights the existence of the ... Read more

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Case Report   |   10.36959/595/411 Volume 4 Issue 1

Pediatric RCVS in Newly Diagnosed all Treated with Intra- Arterial Nicardipine

Authors: Devin Simon, MD, Jaclyn Peraino, BS, Kabelo Thusang, MD and Suhad Khalil, MD
Reversible Cerebral Vasoconstriction Syndrome (RCVS) is an uncommon cause of severe headache and other complications in the pediatric population. Diagnosis includes obtaining vessel imaging to confirm... Read more

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Commentaries   |   10.36959/595/410 Volume 4 Issue 1

Step-By-Step Approach in Managing Sleep Problem in Children with Intellectual Disability

Authors: CHOW Chit Kwong
We must emphasize the first step of management is correct identification of children with sleep disorders, and those with risk factors should receive extra attention. Children with ID are already a hi... Read more

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Case Report   |   10.36959/595/409 Volume 4 Issue 1

Food Color Additives in the US Food Supply: Review of Neurobehavioral Safety

Authors: G Craig Llewellyn, PhD, J Kim Penberthy, PhD and Julia M Parker, BA
Currently approved food additives, including color additives, have a long history of safe use in human consumables. Many food additives are added to increase the flavor or other sensory appeal of food... Read more

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Case Report   |   10.36959/595/408 Volume 4 Issue 1

X-Linked Periventricular Nodular Heterotopia a Rare Cause of Headache and Right Sided Hemiparesis in a 7-Year-Old Girl

Authors: Christine Loftis, BS, Aleksandr Chernyy, MD and Randy Williamson, MD
X-linked Periventricular Nodular Heterotopia (X-linked PVNH) is a neuronal migration disorder that occurs because nerve cells fail to migrate during fetal development. The disorder is caused by a defe... Read more

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Short Communication   |   10.36959/595/407 Volume 4 Issue 1

Authors: Nobuhiko Aoki, MD
This entity is characterized by an extremely stereotypical clinical profile illustrated by the following hypothetical case: A Japanese male infant aged 5 ~12 months falls and hits his occipital region... Read more

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Case Report   |   10.36959/595/406 Volume 4 Issue 1

Infantile Acute Subdural Hematoma with Retinal Hemorrhage Caused by Minor Occipital Impact Witnessed by an ICU Nurse: A Case Report

Authors: Nobuhiko Aoki, M.D
An acute subdural hematoma (ASDH) in infants without external signs of trauma is differently recognized as shaken baby syndrome (SBS) or abusive head trauma (AHT) in the United States or as infantile ... Read more

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Review Article   |   10.36959/595/405 Volume 4 Issue 1

Diffuse Leptomeningeal Glioneuronal Tumor: Case Report and Review of Literature

Authors: Neelan J Marianayagam, MD, PhD, Netanel Ben-Shalom, MD, Helen Toledano, MD, Nevo Marglit, MD, Shalom Michowiz, MD and Gustavo Rajz, MD
In this study, we describe a rare case of disseminated CNS malignancy of childhood. A seven-year-old boy with headache, vomiting and gait disturbances was diagnosed with non-obstructive hydrocephalus ... Read more

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Short Commentary   |   10.36959/595/404 Volume 3 Issue 1

Virtual Academic Units within UK Infrastructure for Research that Benefits Infants, Children and Young People

Authors: Andrew N Williams
I believe that Virtual Academic Units or their equivalent are an extremely cost effective means of augmenting research capacity in areas which previously would not have been done and bringing in ne... Read more

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Review Article   |   10.36959/595/403 Volume 3 Issue 1

The Effect of Seizures on Sleep and Behavior in Children

Authors: Toni Barkley
Children with seizures experience a wide range of different problems that are a result of their different forms of epilepsy. Some problems children experience are sleep disturbances, behavior issues o... Read more

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Review Article   |   10.36959/595/402 Volume 2 Issue 1

Incidence of Inborn Errors of Metabolism in Sick Neonates in a Tertiary Care Hospital in Developing Country

Authors: Mizanur Rahman, Kanij Fatema and Shahidullah
The term "inborn errors of metabolism" (IEM), also referred to as congenital metabolic diseases, is described as the hereditary deficiency of enzymes or alteration in protein structure and function re... Read more

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Review Article   |   10.36959/595/401 Volume 2 Issue 1

A Possible Association between Arnold-Chiari Type I Malformation and Epilepsy: Case Series and Review

Authors: Uri P Hadelsberg, Hadassah Goldberg, Neelan J Marianayagam and Gustavo Rajz
Hans Chiari is the one credited with diagnosing Chiari malformations, dating back to 1890. Chiari malformations consists of four types of hindbrain abnormalities with the majority being a type I or ty... Read more

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Review Article   |   10.36959/595/400 Volume 2 Issue 1

The Role of Interleukins in Epileptic Encephalopathies and Immunomodulation with Adrenocorticotropic Hormone

Authors: Diana C Benitez Ramirez and Angelica M Uscategui Daccaret
Epileptic encephalopathies make up a group of electroclinical syndromes that are characterized by to have an established presenting age, clinical neurological deterioration secondary to persistent epi... Read more

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Case Report   |   10.36959/595/399 Volume 2 Issue 1

Cerebellar Vermian Dysplasia: The Tale of the Tail

Authors: Teresa Chapman and Raj P Kapur
A recently described feature of cerebellar vermian dysplasia, the cerebellar "vermian tail", is a morphologically distinctive dysplasia of the nodular lobule of the posterior cerebellum that is apprec... Read more

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Case Report   |   10.36959/595/398 Volume 2 Issue 1

Intradiploic Skull Hematoma in Infants: An Underestimated Diagnosis

Authors: Ahmed El Damaty, Samer K Albabaa, Andreas Unterberg and Heidi Baechli
Intradiploic hematoma was first reported in 1934 by Chorbski and Davis. It usually occurs after a mild trauma where a small bleeding accumulates within the diploe in between the tabula interna and ext... Read more

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Clinical Case   |   10.36959/595/397 Volume 1 Issue 1

Stroke in a Child: The Role of Mycoplasma Pneumoniae and Coagulation Factor VIII

Authors: Paolo Mariotti, Valerio De Stefano, Maria Chiara Stefanini, Marco Piastra, Francesco Antonio Losavio and Viviana Nociti
A 6-year-old child was admitted for an episode of generalized seizures. Shortly after admission in our Emergency Room, he developed somnolence and meningismus (GCS score 3).... Read more

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ORIGINAL RESEARCH   |   10.36959/595/396 Volume 1 Issue 1

Reliability of the Location of Primary Motor Cortex Using the International 10/20 Electroencephalogram System (10/20 EEG)

Authors: Tonya L Rich, Maíra Lixandrão, Alli Hoefer, Alexa Horning, Rachel Johnson, Steven Kim, and Bernadette Gillick
In stroke recovery, the activation of the primary motor cortex (M1) is critical for motor learning and has been found to be augmented by non-invasive brain stimulation (NIBS) recovery. One form of int... Read more

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Hypothesis   |   10.36959/595/395 Volume 1 Issue 1

A New Pharmacologic Approach for the Potential Reduction of Autism and Multiple Sclerosis

Authors: Gary Steinman
Multiple sclerosis and autism bear significant neuropathologic similarities such as reduced myelination and elevated anti-myelin basic protein (anti-MBP). However, the ages at which multiple sclerosis... Read more

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