Journal of Pediatric Neurology and Neuroscience

ISSN: 2642-4797

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Case report | VOLUME 5 | ISSUE 2 | DOI: 10.36959/595/425 OPEN ACCESS

Reversible MRI Changes in the Splenium Related to Recent Cessation of Antiepileptic Medications

McLaren J, Misra A and Chu CJ

  • McLaren J 1*
  • Misra A 1
  • Chu CJ 1,2
  • Department of Neurology, Massachusetts General Hospital, USA
  • Harvard Medical School, USA

McLaren J, Misra A, Chu CJ (2021) Reversible MRI Changes in the Splenium Related to Recent Cessation of Antiepileptic Medications. J Pediatr Neurol Neurosci 5(2):141-141.

Accepted: July 22, 2021 | Published Online: July 24, 2021

Reversible MRI Changes in the Splenium Related to Recent Cessation of Antiepileptic Medications

Case


A 21-year-old male with history of refractory epilepsy presented for long-term video EEG monitoring. His home antiepileptic medications were weaned off over a seven-day period. On hospital day 4, he had a right temporal electro clinical seizure with secondary generalization and a second right temporal electrographic seizure. On hospital day 8, MRI brain identified an ovoid circumscribed lesion in the splenium of the corpus callosum which had not been present on prior scans (Figure 1). This characteristic lesion is thought to be induced by a rapid reduction of antiepileptic drugs, not with toxic drug effects or seizure frequency. It requires no further investigation [1].

References


  1. Gürtler S, Ebner A, Tuxhorn I, et al. (2005) Transient lesion in the splenium of the corpus callosum and antiepileptic drug withdrawal. Neurology 65: 1032-1036.