Insights of Biomedical Research

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Case Report   |   10.36959/584/453 Volume 3 Issue 1

Reversible Cardiotoxicity in a Young Patient Treated with Trastuzumab for Breast Cancer: A Case Report

Authors: Ould Amar N, Ben Bachir H, Senhadji I, Bessaih N and Toumi H

Abstract: We report the case of a young patient with left breast cancer with stage IIB (T2N1M0), negative hormone receptors, HER2-positive and no particular medical history. The patient was particularly sensitive to the neurological and allergic- type toxicity of the adjuvant treatment she received and it required the stopping and successive change of the various prescribed protocols. Trastuzumab was continued as monotherapy for one year; asymptomatic cardiotoxicity was reported following the fall in LVEF (a 17.9% drop from baseline with a value below 50%).


Research Article   |   10.36959/584/452 Volume 3 Issue 1

Effect of Vitamin D Supplementation on Clinical and Radiographic Evaluation of Oral Rehabilitation with Osseointegrated Implants

Authors: Adriano Piccolotto, Gisele Toyama, Mauro Busato and Adriane Yaeko Togashi

Abstract: Vitamin D (VD) is important for the development and maintenance of bone tissue. This study used clinical and radiographic evaluations to analyze whether insufficient VD levels affect the peri-implant health of patients with implant-supported prostheses. Data were collected for 33 patients with implant-supported prostheses: Probing depth (PD); width of keratinized mucosa (wKM); bleeding (mBI); peri-implant plaque index (mPI); distance from implant to bone crest and VD level. Patients with levels under 30 ng/ml at baseline received 50000 IU of VD per week for 8 weeks (post-treatment, PT),


Review Article   |   10.36959/584/451 Volume 3 Issue 1

An Overview of Sixteen Years Control Program against Rift Valley Fever in Saudi Arabia: A Review Study

Authors: Mutaz S Alhaj

Abstract: Rift Valley Fever (RVF) is a serious life-threatening disease with severe clinical manifestations and health consequences for humans and a wide range of domestic animals. In September 2000, a RVF outbreak was reported in Jazan region south-west Saudi Arabia with 886 human cases including 124 deaths. This review provides: 1) An overview of RVF control program in Saudi Arabia and current control measures; 2) A feasibility assessment of some intervention measures that have been launched since the early recognition of RVF.


Case Study   |   10.36959/584/450 Volume 3 Issue 1

Adrenal Lesion Core Biopsy: A New Approach and an Incidental Benefit

Authors: Kim Smith

Abstract: A 79-year-old male with a history of renal cell carcinoma was referred for CT guided core biopsy of a right sided 3 cm adrenal lesion. A number of vulnerable anatomical structures were adjacent to the lesion, so an innovative positioning technique was used to maximize access to the lesion and minimize risk to the adjacent structures. The head down position used in this case resulted in the liver and portal vein moving superiorly, significantly reducing the likelihood of injury.


Research Article   |   10.36959/584/449 Volume 3 Issue 1

Iatrogenic Bile Duct Injury and Its Management with Intensive Care Unit Process: A Single-Center Experience

Authors: Ibrahim Mungan, Sema Turan, Busra Tezcan, Bahar Aydinli, Erdal Birol Bostanci and Bulent Odemis

Abstract: The delayed recognition of bile duct injury (BDI) and the challenges in its diagnosis lead to clinical variability. The management of BDI is complicated and ranges from ERCP to liver transplantation. But infections related to BDI and sepsis control, prior to the bile flow reestablishment, are the mainstay of the treatment. In this study, we aimed to report the clinical outcomes of iatrogenic BDI and intensive care unit (ICU) process in a tertiary state hospital.


Research Article   |   10.36959/584/448 Volume 3 Issue 1

Functions of Conserved Domains of Human Polynucleotide Phosphorylase on RNA Oxidation

Authors: Sulochan Malla and Zhongwei Li

Abstract: Human polynucleotide phosphorylase (hPNPase), an exoribonuclease that is primarily localized in mitochondria, plays an important role in reducing oxidized RNA and protecting cells under oxidative stress conditions. hPNPase contains two catalytic domains (RPH1 and RPH2) and two RNA binding domains (KH and S1), and an N-terminal mitochondrial translocation signal (MTS).


Research Article   |   10.36959/584/446 Volume 3 Issue 1

Comparison of the Hyponatremic Effects of Erythropoietin and U-74389G

Authors: Constantinos Tsompos, Constantinos Panoulis, Konstantinos Toutouzas, Aggeliki Triantafyllou, George C Zografos, Kalliopi Tsarea, Maria Karamperi and Apostolos Papalois

Abstract: This study calculated the effects on serum sodium (Na) levels, after treatment with either of 2 drugs: The erythropoietin (Epo) and the antioxidant lazaroid (L) drug U-74389G. The calculation was based on the results of 2 preliminary studies, each one of which estimated the certain influence, after the respective drug usage in an induced ischemia reperfusion (IR) animal experiment.


Review Article   |   10.36959/584/447 Volume 3 Issue 1

A New Biophysical Analysis of the Twin Paradox: The Interaction between Velocity and the Variable Biological Clock

Authors: Fred H Thaheld

Abstract: Initial analysis of the twin paradox from a biophysical standpoint appears to reveal a new additional consideration that has been overlooked for over a century. That the traveling twin may come back even younger than has previously been considered due to his variable daily metabolic cycle or variable biological clock, with special emphasis on his period of sleep involving his normally slowed biological clock, becoming minutely further slowed during each such cycle, due to velocity continuing to interact with this reduced base rate and in accordance with the Lorentz factor.


Commentary Article   |   10.36959/584/445 Volume 3 Issue 1

Management of Elderly Patients with Diabetes Mellitus from Patient-Centered Medicine

Authors: Hiroshi Bando, MD, PhD

Abstract: Diabetes mellitus has become more important health problem across the world. Among them, it is not simply a medical problem with excess calories and obesity, but various differences and issues are found in several situation. Even if the value of HbA1c is same, the guidance for standard regular diet is not the same between for the younger group and the elderly group.


Research Article   |   10.36959/584/444 Volume 3 Issue 1

In vitro Technical Aspects of Anti-Gene IGF-I Vaccines against Glioma

Authors: Jerzy Trojan, Tatiana Castillo, Gabriela Quintero, Adama Ly, Pedro Penagos, Alexander Shevelev, You-Chun Lone, Edwin Paez, Oscar Gutierrez, Ignacio Briceno, Maciej Bierwagen, Carlos Rojas, Jaime Arias, Heliodor Kasprzak, Adis Ayala, Yuexin X Pan and Annabelle Trojan

Abstract: Research on glioblastoma has demonstrated a significant increase in IGF-I gene expression in this brain tumor. After suppression of IGF-I expression using anti-gene IGF-I technologies, glioma cells become immunogenic, expressing MHC-I. While injected in vivo, they induce an immune response mediated by T-CD8 lymphocytes. These cells, applied as autologous anti-cancer vaccines have increased the median survival of glioblastoma patients up to 18 months, but often up to two-three years.


Opinion   |   10.36959/584/443 Volume 2 Issue 1

Need for Physician Empowerment in front of Artificial Intelligence Overruling

Authors: Francis Roger France

Abstract: Artificial Intelligence (AI) has become an essential part of the computer technology industry. Machine learning, knowledge engineering, patterns identification, problem solving and robots are making important progresses. Health care might benefit from these new tools by helping physicians to make decisions in complex clinical situations, to diagnose diseases, to recognize images, to adapt treatments to individual cases and even to interact by using robots allowing object manipulation. However, machine capabilities depend on human programming choices. Furthermore, AI can only be as smart as the data set served.


Research Article   |   10.36959/584/442 Volume 2 Issue 1

Influence of Confounding Evidence Based Risk Factors Triggering the Incidence of HIV Antibodies among Screened Population of Niger Delta Extraction

Authors: Azuonwu Obioma and Azuonwu Testimonies Chikanka

Abstract: The Human Immunodeficiency Virus (HIV) is transmittable through body fluids such as blood, breast milk and semen. Determination of its prevalence and associated risk factors are important especially in rural areas where the dwellers pay little or no concern to their health. This study was carried out in seven locations in Ahoada East Local Government Area of Rivers State, thus 1000 subjects were purposively recruited and screened for HIV1 and HIV1 and 2 respectively.


Research Article   |   10.36959/584/441 Volume 2 Issue 1

Utility of Exome Sequencing Databases in Validating Genetic Variants Associated with Multiple Endocrine Neoplasia

Authors: Tyler J Mouw, Alexander Balmaceda, Tejal Brahmbhatt and Peter J DiPasco

Abstract: Multiple Endocrine Neoplasia (MEN) syndromes and Familial Medullary Thyroid Cancer have a well-documented genetic origin; However, it is not always clear whether genetic variation represents a pathologic vs. normal rare variant.


Letter To Editor   |   10.36959/584/440 Volume 2 Issue 1

Fluoroquinolones Awareness Cipro/ciprofloxacin, Levaquin/levofloxacin, Avelox/moxifloxacin

Authors: Charles C Maack

Abstract: Please recognize that I am not a Medical Doctor. Rather, I do consider myself a medical detective. I have been an avid student researching and studying prostate cancer as a survivor and continuing patient since 1992. I have dedicated my retirement years to continued deep research and study in order to serve as an advocate for prostate cancer awareness, and, from an activist patient's viewpoint, as a mentor to voluntarily help patients, caregivers, and others interested develop an understanding of this insidious men's disease, its treatment options, and the treatment of the side effects that often accompany treatment.


Research Article   |   10.36959/584/439 Volume 1 Issue 1

A Study of Nuclear Medicine Contrast Retention in Vascular Access Ports

Authors: Michael S Gossman, Huaiyu Zheng, Junling Li and Chin K Ng

Abstract: Vascular access ports were investigated to determine the retention rate of injected radiotracers during PET scan acquisition. A total of 30 ports were tested, including 3 different port models from a single manufacturer.


Research Article   |   10.36959/584/438 Volume 1 Issue 1

Investigation of MRI Contrast Release from Vascular Access Ports after Priming

Authors: Michael S Gossman, Zhu Mingming, Huaiyu Zheng and Chin K Ng

Abstract: Vascular ports designed for venous access were injected with gadolinium contrast and imaged using MRI. Incrementally, the ports were flushed with saline and scanned to determine the amount of flush volume necessary to rid the injected gadolinium.


Research Article   |   10.36959/584/437 Volume 1 Issue 1

Dimensional Analysis and Constitutive Equations of Quantitative Microdialysis

Authors: CF Chen

Abstract: As a membrane-based sampling technique microdialysis can be quantified by the relative recovery and the time-to-reach-the-steady-state in sampling. In this paper dimensional analysis is applied to show that the performance can be collectively determined by three dimensionless numbers, the P├ęclet and Reynolds numbers of the perfusion flow and the membrane-to-channel area ratio.


Research Article   |   10.36959/584/436 Volume 1 Issue 1

Vitamin D Levels in Women with Intrahepatic Cholestasis of Pregnancy

Authors: Emre Canverenler, Baris Buke, Hatice Akkaya, Mustafa Bertan Demir, Cagri Guven and Gursen Gundem

Abstract: To evaluate the relationship between plasma 25-hydroxyvitamin D (25(OH)D) levels in Intrahepatic Cholestasis of Pregnancy (ICP) patients.


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