Insights of Biomedical Research

 ISSN: 2642-4576

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Case Study   |   10.36959/584/450 Volume 3 Issue 1

Adrenal Lesion Core Biopsy: A New Approach and an Incidental Benefit

Authors: Kim Smith

Abstract: A 79-year-old male with a history of renal cell carcinoma was referred for CT guided core biopsy of a right sided 3 cm adrenal lesion. A number of vulnerable anatomical structures were adjacent to the lesion, so an innovative positioning technique was used to maximize access to the lesion and minimize risk to the adjacent structures. The head down position used in this case resulted in the liver and portal vein moving superiorly, significantly reducing the likelihood of injury.


Research Article   |   10.36959/584/449 Volume 3 Issue 1

Iatrogenic Bile Duct Injury and Its Management with Intensive Care Unit Process: A Single-Center Experience

Authors: Ibrahim Mungan, Sema Turan, Busra Tezcan, Bahar Aydinli, Erdal Birol Bostanci and Bulent Odemis

Abstract: The delayed recognition of bile duct injury (BDI) and the challenges in its diagnosis lead to clinical variability. The management of BDI is complicated and ranges from ERCP to liver transplantation. But infections related to BDI and sepsis control, prior to the bile flow reestablishment, are the mainstay of the treatment. In this study, we aimed to report the clinical outcomes of iatrogenic BDI and intensive care unit (ICU) process in a tertiary state hospital.


Research Article   |   10.36959/584/448 Volume 3 Issue 1

Functions of Conserved Domains of Human Polynucleotide Phosphorylase on RNA Oxidation

Authors: Sulochan Malla and Zhongwei Li

Abstract: Human polynucleotide phosphorylase (hPNPase), an exoribonuclease that is primarily localized in mitochondria, plays an important role in reducing oxidized RNA and protecting cells under oxidative stress conditions. hPNPase contains two catalytic domains (RPH1 and RPH2) and two RNA binding domains (KH and S1), and an N-terminal mitochondrial translocation signal (MTS).

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Research Article   |   10.36959/584/446 Volume 3 Issue 1

Comparison of the Hyponatremic Effects of Erythropoietin and U-74389G

Authors: Constantinos Tsompos, Constantinos Panoulis, Konstantinos Toutouzas, Aggeliki Triantafyllou, George C Zografos, Kalliopi Tsarea, Maria Karamperi and Apostolos Papalois

Abstract: This study calculated the effects on serum sodium (Na) levels, after treatment with either of 2 drugs: The erythropoietin (Epo) and the antioxidant lazaroid (L) drug U-74389G. The calculation was based on the results of 2 preliminary studies, each one of which estimated the certain influence, after the respective drug usage in an induced ischemia reperfusion (IR) animal experiment.

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Review Article   |   10.36959/584/447 Volume 3 Issue 1

A New Biophysical Analysis of the Twin Paradox: The Interaction between Velocity and the Variable Biological Clock

Authors: Fred H Thaheld

Abstract: Initial analysis of the twin paradox from a biophysical standpoint appears to reveal a new additional consideration that has been overlooked for over a century. That the traveling twin may come back even younger than has previously been considered due to his variable daily metabolic cycle or variable biological clock, with special emphasis on his period of sleep involving his normally slowed biological clock, becoming minutely further slowed during each such cycle, due to velocity continuing to interact with this reduced base rate and in accordance with the Lorentz factor.

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Commentary Article   |   10.36959/584/445 Volume 3 Issue 1

Management of Elderly Patients with Diabetes Mellitus from Patient-Centered Medicine

Authors: Hiroshi Bando, MD, PhD

Abstract: Diabetes mellitus has become more important health problem across the world. Among them, it is not simply a medical problem with excess calories and obesity, but various differences and issues are found in several situation. Even if the value of HbA1c is same, the guidance for standard regular diet is not the same between for the younger group and the elderly group.

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Research Article   |   10.36959/584/444 Volume 3 Issue 1

In vitro Technical Aspects of Anti-Gene IGF-I Vaccines against Glioma

Authors: Jerzy Trojan, Tatiana Castillo, Gabriela Quintero, Adama Ly, Pedro Penagos, Alexander Shevelev, You-Chun Lone, Edwin Paez, Oscar Gutierrez, Ignacio Briceno, Maciej Bierwagen, Carlos Rojas, Jaime Arias, Heliodor Kasprzak, Adis Ayala, Yuexin X Pan and Annabelle Trojan

Abstract: Research on glioblastoma has demonstrated a significant increase in IGF-I gene expression in this brain tumor. After suppression of IGF-I expression using anti-gene IGF-I technologies, glioma cells become immunogenic, expressing MHC-I. While injected in vivo, they induce an immune response mediated by T-CD8 lymphocytes. These cells, applied as autologous anti-cancer vaccines have increased the median survival of glioblastoma patients up to 18 months, but often up to two-three years.

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Journal Details
  1. Journal: Insights of Biomedical Research
  2. ISSN: 2642-4576
  3. ISO abbreviation: Insights Biomed Res
  4. Other Title: IBR
  5. Pub Type: Open Access