Journal of Neurodegenerative Disorders

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Editorial   |   10.36959/459/609 Volume 5 Issue 1

Deep Brain Stimulation or Pallidotomy for Dystonia in Neurodegeneration with Brain Iron Accumulation? A Call for Justice to the Balance

Authors: David Armando Guach‑Hevia, MD
Neurodegeneration with brain iron accumulation (NBIA) comprises a group of rare but devastating inherited neurological diseases with unifying features of gradual cognitive and motor decline, and progr... Read more

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Review Article   |   10.36959/459/608 Volume 5 Issue 1

Similarities among Alzheimer's Disease, Parkinson's Disease and Dementia may Call for a Similar Treatment

Authors: Ashok Chakraborty, PhD and Anil Diwan, PhD
Alzheimer's Disease (AD), Parkinson's Disease (PD), and Dementia are all age-related neurodegenerative diseases. In the US, AD victims are increasing every year from 5.5 million in 2018 to 13.8 millio... Read more

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Case Presentation   |   10.36959/459/607 Volume 5 Issue 1

A Case of C9orf72-Associated Behavioral Variant of Frontotemporal Lobe Degeneration Presenting with Multiple Suicide Attempts

Authors: Cunha e Costa N, Diniz Gomes R, Descalço N, Mota AM, Sobreira G, Ribeiro AC and Moutinho FS
Frontotemporal lobe degeneration (FTLD) comprises a spectrum of clinical syndromes that includes multiple neurodegenerative disorders with different neuropathological pathways that lead to a common fr... Read more

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Research Article   |   10.36959/459/606 Volume 4 Issue 1

The Experience of Parkinson’s Disease in Hai District, Tanzania

Authors: Natasha Fothergill-Misbah, Catherine Dotchin, John Kisima, Kate Hampshire, and Richard Walker
Parkinson’s disease (PD) is a debilitating neurological disease that can result in a reduced quality of life for people with Parkinson’s disease (PwP) and their families. The incidence of PD conti... Read more

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Review Article   |   10.36959/459/605 Volume 4 Issue 1

Role and Molecular Mechanisms of Lysosomes and Cathepsins in Neuropathology and Aging: New Insights

Authors: Muhammad Babar Khawar, Naz Fatima, Muddasir Hassan Abbasi, Nadeem Sheikh, Hafiza Nabeela Amaan, Rabia Mehmood, Maryam Mukhtar, Amin Arif, Zaira Ahmad, Zerwa Siddique, Adil Farooq and Tahaa Saeed
Lysosomes are the major catabolic entities that target a large number of biomolecules and pathogens as well. These cytoplasmic organelles play a substantial role in maintaining homeostasis with the a... Read more

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Systematic Review   |   10.36959/459/604 Volume 4 Issue 1

Effectiveness of Repetitive Transcranial Magnetic Stimulation on Freezing of Gait in Parkinson's Disease Patients: A Systematic Review of the Literature

Authors: Wael Ibrahim, MD
Episodes of FOG is often a debilitating event occurring in patients with Parkinson's disease (PD). TMS has been studies as a treatment options for a number of neuropsychiatric disorders including depr... Read more

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Review Article   |   10.36959/459/603 Volume 3 Issue 1

Dementia Research Activity in Sri Lanka: A Review

Authors: Kalpani Abhayasinghe, Lasith Dissanayake, Benjamin Saunders, Paul Campbell and Athula Sumathipala
As a result of the global rise in life expectancy, dementia has become a major global health concern; it is considered to be one of the most burdensome conditions of later life. Despite 66% of older a... Read more

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Case Presentation   |   10.36959/459/602 Volume 3 Issue 1

Obtaining Clinical Improvement in Amyotrophic Lateral Sclerosis with Stabilization of Progressive Functional Loss: Case Report Presentation and Review

Authors: Allen J Orehek
The patient was given the diagnosis during evaluation at a comprehensive amyotrophic lateral sclerosis (ALS) center by the neurology team. During the year prior to the diagnosis of ALS the patient was... Read more

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Research Article   |   10.36959/459/601 Volume 3 Issue 1

Aquaporin-4 Inhibition Mediates Piroxicam-Induced Neuroprotection against Focal Cerebral Ischemia/Reperfusion Injury in Rodents

Authors: Pallab Bhattacharya, Anand Kumar Pandey, Sudip Paul and Ranjana Patnaik
Brain edema due to the over expression of AQP4 is a major determinant for progression of neuronal insult during ischemic stroke. During brain pathology, both down regulation and up regulation of AQP4 ... Read more

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Review Article   |   10.36959/459/560 Volume 3 Issue 1

Eilepsy as a First Symptom of the Alzheimer's Disease: A Narrative Review

Authors: Francesco Raudino
The frequency of seizures as a first sign of the AD is probably underestimated. The physician should be aware that seizures of unknown origin among the elderly could be the first sign of the AD. Besid... Read more

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Research Article   |   10.36959/459/600 Volume 3 Issue 1

Blueprint for a Brain Health Clinic to Detect and Manage Early-Stage Cognitive Decline: A Consensus Exercise

Authors: Iracema Leroi, Charlotte Peel, Rebecca Davenport, Ross Dunne, Louise Ebenezer, Mahesh Gopakumar, Vachagan Krishnaswami, Jane Lumsden, Helen Martin, Jane Price and Wilby Williamson
It is possible that about 30% of all dementia is preventable by addressing many of the modifiable health and lifestyle risks important for overall physical health. Currently, people in the pre-dementi... Read more

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Review Article   |   10.36959/459/598 Volume 2 Issue 1

Epilepsy Increase in the Elderly: Role of not Evolutive Epileptogenic Brain Lesions (NEEBLs)

Authors: Domenico Chirchiglia
Epilepsy in the elderly is a very debated case because much depends on the causes and associated pathologies. In particular, in the presence of comorbidity it is often difficult to find an effective a... Read more

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Orginal Research   |   10.36959/459/597 Volume 2 Issue 1

Near Infrared Spectroscopy alike Magnetic Resonance Imaging: Complementary Data in Rat Brain after Cocaine Treatment

Authors: Francesco Crespi, Francesca Formenti and Francesco Congestri
Magnetic Resonance Imaging (MRI) and Near Infrared Spectroscopy (NIRS) are two major in vivo non invasive methodologies more and more applied in research. The first more than the second is largely use... Read more

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Case Report   |   10.36959/459/596 Volume 2 Issue 1

The Dilemma of Raised Blood Levels of Folate and B12 in Autism

Authors: D Lonsdale
It has recently been reported that a raised level of folate and/or vitamin B12 in the blood of a newly parturient woman forecasts a marked increase in the possibility that the newborn infant will late... Read more

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Original Article   |   10.36959/459/595 Volume 2 Issue 1

Salvia Hispanica L (Chia Seeds) as Brain Superfood-How Seeds Increase Intelligence

Authors: Peter Onneken
The influence of nutrition on cognitive abilities is undisputed in academic literature. Numerous studies have shown that the effects of polyunsaturated fats and other foods, such as milk, meat or oils... Read more

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Research Article   |   10.36959/459/594 Volume 2 Issue 1

Translational NIRS: Parallel Alteration of Brain Metabolism Following Alcohol Intake in Rodents and Man

Authors: Francesco Crespi, Francesco Congestri and Maurizio Donini
Near-infrared spectroscopy (NIRS) provides a non-invasive, non-ionizing means to monitor total haemoglobin concentration and oxygen saturation in the living tissue allowing monitoring oxygen sufficien... Read more

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Case Report   |   10.36959/459/593 Volume 1 Issue 1

Cerebrotendinous Xanthomatosis: Literally an Orphan Disease in Brazil: Case Report

Authors: Emanuelle Bianchi da Silva, Brenda Camila Reck de Oliveira, Taline Alisson Artemis Lazzarin Silva, Letícia da Silva Schran and Paulo Eduardo Mestrinelli Carrilho
Cerebrotendinous Xanthomatosis (CX) is an exceedingly rare autosomal recessive lipid storage disorder due to homozygous mutation of the mitochondrial enzyme sterol 27-hydroxylase.... Read more

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Case Report   |   10.36959/459/592 Volume 1 Issue 1

Caregiver Syndrome

Authors: Neslihan Lok and Kerime Bademli
Caregiver syndrome is caused by continuous care without interrupting a chronic patient. The physical, emotional and economic difficulties experienced by caregivers, the losses in the functioning of th... Read more

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short communication   |   10.36959/459/591 Volume 1 Issue 1

Effects of Surface Tissue Compression on Muscle Tone of Stroke Patients

Authors: Crislaine de Lima, Vanessa de Fatima Dias, Gabriel Padua da Silva, Evandro Marianetti Fioco, Camila Roza Goncalves, Oswaldo Stamato Taube, Saulo Fabrin, Simone Cecilio Hallak Regalo and Edson Donizetti Verri
There are two types of cerebrovascular accident, or stroke. An ischemic stroke is caused by a blockage of blood flow, and a hemorrhagic stroke is caused by a breakage in a blood vessel.... Read more

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Research Article   |   10.36959/459/590 Volume 1 Issue 1

Evaluation of the Elderly Living in the Central Kirşehir Using Standardized Mini-Mental State Examination

Authors: Gokce Demir, Ayla Unsal, Safak Taktak and Sevil Bicer
In the last century technological developments contribute positively to the living conditions, quality improvement in health care, higher levels of education, advances in public health and preventive ... Read more

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Research Article   |   10.36959/459/589 Volume 1 Issue 1

Lessons from the Discovery of the "Calcium Paradox" due to Ca2+/Camp Interaction

Authors: Leandro Bueno Bergantin and Afonso Caricati-Neto
The notion of stimulus-secretion initially resulted from the experiments performed by Douglas and Rubin in the sixties. Using adrenal chromaffin cells, Baker and Knight revealed in seventies that a ri... Read more

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