Chromatography and Spectroscopy Techniques

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Research Article   |   10.36959/326/768 Volume 2 Issue 1

The Influence of UV Irradiation on Diabetic Mice Skin: A Vibrational FT-IR and Raman Spectroscopic Study

Authors: J Anastassopoulou, M Kyriakidou, V Mamareli, O Tanis and M Rallis

Abstract: The aim of this study was to investigate the effect of UV irradiation on streptozotocin-induced diabetic skin. 42 hairless male mice were divided into three groups of control non-diabetic and with dose of streptozotocin 20 and 30 mg/kg. Both FT-IR and Raman spectra showed considerable changes between the diabetic and non-diabetic mice, as well as after irradiation. The most important changes between healthy and diabetic groups were observed in the reduction

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Research Article   |   10.36959/326/767 Volume 2 Issue 1

Isolation, Purification and Structural Identification of Degradation Products from Ketoconazole in a Liquid Formulation: An HPLC and HPLC-MS/MS Study

Authors: Fa Zhang, Ph.D

Abstract: Ketoconazole is the active ingredient in an antifungal liquid formulation for topical application. A binary gradient HPLC analysis indicated that ketoconazole in the formulation produced four degradation products at minor levels after storage at room temperature for about 3 years. These degradation products were isolated and purified using semi-preparative HPLC procedures followed by analysis using off-line HPLC-ESI-MS and HPLC-ESI-MS/MS.

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Research Article   |   10.36959/326/766 Volume 1 Issue 1

Synthesis and Preliminary Assays of a Novel Molecularly Imprinted Polymer Dedicated to the Extraction of Carbamazepine from River Water

Authors: Berengere Claude, Syntia Fayad, Christelle Dufresne, Claudine Chatellier, Francois Lestremau, Patrick Rollin, Philippe Morin and Reine Nehme

Abstract: Monitoring of trace organic contaminants in aquatic media has become a major concern today. The presence of Carbamazepine (CBZ), anticonvulsant and analgesic used in the treatment of pain associated with trigeminal neuralgia, has been reported in effluents from sewage treatment plants due to its low biodegradability.

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Editorial   |   10.36959/326/765 Volume 1 Issue 1

Changes at the Surface Electrostatic Activity is Involved in Infectivity and Elimination of Accumulated Prion Proteins

Authors: Aly Moussa

Abstract: The results obtained during the study of mutations on the gene coding for the human prion protein showed that the only major consequence of mutations is the perturbation of the protein surface electrostatic potential which subsequently is responsible for the convergence of PrPc to PrPsc.

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Journal Details
  1. Journal: Chromatography and Spectroscopy Techniques
  2. ISO abbreviation: Chromatogr Spectrosc Tech
  3. Other Title: CST
  4. Pub Type: Open Access