Journal of Brain Disorders

Research Article   |   10.36959/524/336 Volume 4 Issue 1

Feasible Magnetic Induction Tomography for Determining Parkinson’s Disease by Biomarker Imaging

Authors: Hussaini Adam, Subash CB Gopinath, MK Md Arshad and Uda Hashim

In order to support patients suffering from Parkinson’s disease caused by irregular aggregation of alpha-synuclein in the brain, an economically affordable and diagnostically effective modality ... Read more

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Review Article   |   10.36959/524/335 Volume 4 Issue 1

High Wall Shear Incites Cerebral Aneurysm Formation & Low Wall Shear Stress Propagates Cerebral Aneurysm Growth

Authors: Vignarth Shantha Kumar and Vivig Shantha Kumar

Endothelial cells exhibit a variety of structural and functional changes when they come into contact with normal laminar flow. In response to laminar shear stress, endothelial cells modify their potas... Read more

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Research Article   |   10.36959/524/334 Volume 4 Issue 1

Three Phases of Vascular Smooth Muscle Cells in Cerebral Aneurysms: Early Hyperproliferative, Intermediate Dedifferentiated & Late Hypoproliferative

Authors: Vivig Shantha Kumar and Vignarth Shantha Kumar

Vascular smooth muscles play a vital role in the growth and propagation of cerebral aneurysms. These highly dynamic cells, characterized by a high degree of plasticity, show structural and functional ... Read more

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Research Article   |   10.36959/524/333 Volume 4 Issue 1

Alteration of Hemostatic Coagulative Balance in Bacterial Meningitis: Activation of Coagulation & Inhibition of Fibrinolysis

Authors: Vivig Shantha Kumar, Vignarth Shantha Kumar, Niriksha Ravi, Mingma L. Sherpa, Blessing T. Ojinna and Nilasma Shreshta

Bacterial Meningitis is an acute purulent infection of the leptomeninges in the subarachnoid space, most commonly caused by Streptococcus pneumonia, Neisseria meningitidis, and Haemophilus influenzae... Read more

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Research Article   |   10.36959/524/332 Volume 3 Issue 1

Immunotherapy for Glioma

Authors: Li Zhang, Xiao Qi Xie, Chen Yi and Feng Wang

Glioma is the most common intracranial malignancy in the central system. At present, the treatment method of glioma is mainly surgical resection combined with chemotherapy and radiotherapy, but the ma... Read more

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Research Article   |   10.36959/524/331 Volume 3 Issue 1

Adult Vitamin D Deficiency Impairs Hippocampal- Dependent Memory and Proteins Related to Synaptic Plasticity and Metabolism in Mice

Authors: Natalie J Groves, Peter Josh, John J McGrath, Nyoman D Kurniawan and Thomas HJ Burne

Vitamin D deficiency has been associated with a range of neuropsychiatric and neurodegenerative disorders, including schizophrenia, autism, depression, Alzheimer’s disease and cognitive impairment. ... Read more

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Case Presentation   |   10.36959/524/330 Volume 2 Issue 1

Do Not Overlook Zona Herpes Ophthalmicus in a Patient Presenting with Pupil-Sparing Oculomotor Nerve Palsy

Authors: Mehtap Kocaturk, Mustafa Aksoy and Ozcan Kocaturk

Herpes Zoster (HZ), relatively common syndrome, is the result of reactivation of Varicella-Zoster Virus (VZV) that lying in the ganglion after a prior bout of varicella. Reactivation is usually caused... Read more

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RESEARCH ARTICLE   |   10.36959/524/329 Volume 1 Issue 1

Evaluation of Sequential Organ Failure Assessment (SOFA) Performance in Neurocritical Care Patients Overtime: A Retrospective Cohort Study

Authors: Mariana Rabelo de Brito, Alexandre Guimarães de Almeida Barros, Lenise Valler, Fabricio Buchdid Cardoso, Ana Paula Devite Cardoso Gasparotto, Luciana Tiziani Silva, Cristina Bueno Terzi Coelho, Desanka Dragosavac and Antônio Eiras Falcão

Prediction models are widespread used as surrogate markers of disease severity, benchmarking and resource allocation in critical care. After derivation, they should pass through validation in differen... Read more

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SHORT COMMUNICATION   |   10.36959/524/328 Volume 1 Issue 1

The History of Cerebrospinal Fluid Analysis in Multiple Sclerosis: A Great Development over the Last Centuries

Authors: Vecchio Domizia

Cerebrospinal Fluid (CSF) analysis acquired a great role in the 1990's when applied to Multiple Sclerosis (MS) diagnostic work-up. The "watery fluid" by Andreas Vesalius remained unstudied till the in... Read more

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Research Article   |   10.36959/524/327 Volume 1 Issue 1

Effect of Chinese Herbal Medicine Xixin Decoction on Aβ42 and its Regulatory Enzymes in APP/PS1 Double Transgenic Murine Brain

Authors: Diwu Yong-chang, Gu Zan, Cui Na, Yang Ke, Gu Jie, Zeng Jian, Li Xiang, Gao Yan-bin, Tang Xue-cheng and Zhai Jia-ming

To observe the effect of a Xixin decoction on learning and memory in APP/PS1 transgenic mice in addition to hippocampal ultrastructure and hippocampal Aβ42 related regulatory enzymes.... Read more

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Review Article   |   10.36959/524/326 Volume 1 Issue 1

Advances for the Pharmacotherapy of Parkinson's Disease: Pharmacological Handling of the Ca2+/cAMP Signalling Interaction

Authors: Leandro Bueno Bergantin and Afonso Caricati-Neto

Reduction of dopamine release from striatal dopaminergic neurons due to neuronal death is the main accepted concept of Parkinson's disease. Parkinson's disease begins years before a clinical diagnosis... Read more

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Review Article   |   10.36959/524/325 Volume 1 Issue 1

Statins as an Adjuvant Therapy for Psychotic Disorders: Current Evidence with a Systematic Overview of Double-Blind Placebo-Controlled Trials

Authors: Tjardo S Postma, Lyliana G Nasib, Maya J L Schutte, Marc M Bohlken, Peter Martens, Erna van't Hag, Selene R T Veerman, Marieke J H Begemann and Iris E C Sommer

Evidence is accumulating that inflammatory processes play a role in the pathophysiology of schizophrenia. This suggests that anti-inflammatory drugs might have beneficial effects in the treatment of s... Read more

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Research Article   |   10.36959/524/324 Volume 1 Issue 1

Perinatal Administration of Caffeine in Mice Affects the Spatial Memory and Motor Coordination Later in Adult Life

Authors: Alsayed A, Jamal M, Al Hoty N, Eqab S, Ahmadi N, Sameer M, Alathem A, Al Saqer M, Alsulami B and Kamal A

Data emerging that maternal consumption of moderate amount of caffeine will affect the development of the fetus and later the cognitive function of the brain. The aim of this study was to determine th... Read more

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Review Article   |   10.36959/524/323 Volume 1 Issue 1

The Discovery of the "Calcium Paradox" Due to Ca²⁺/Camp Interaction: Novel Adventures for the Pharmacotherapy of Neurological/Psychiatric Disorders

Authors: Leandro Bueno Bergantin and Afonso Caricati-Neto

Our discovery of the involvement of the interaction between intracellular signalling pathways mediated by Ca²⁺ and cAMP (Ca²⁺/cAMP interaction) in the neurotransmission and neuro... Read more

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