Alzheimers Disease & Dementia Archives

Review Article | 10.36959/734/386 Volume 7 Issue 1

A Systematic Review on the Pharmacologic Treatment of Apathy in Dementia

Authors: Lovelle G. Ditucalan, MD, Encarnita R. Ampil, MD, FPNA, Ma. Lourdes C. Joson, MD, FPNA, Steven G. Villaraza, MD, FPNA and Joseree-Ann S. Catindig, MD, FPNA

Dementia is a neurocognitive disorder that causes functional impairment usually accompanied by neuropsychiatric symptoms. Majority of individuals with dementia suffer from behavioral dysfunction. Apat... Read more

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Review Article | 10.36959/734/385 Volume 6 Issue 1

Role of Extracellular Matrix Stiffness Inhibitors in Alzheimer's Disease

Authors: Garry Kerch

Alzheimer’s disease is closely related with ageing and age-related extracellular matrix stiffness increase. The association between stiffness and NF-kB activation was demonstrated and link between t... Read more

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Research Article | 10.36959/734/384 Volume 5 Issue 2

Himalayan Pink Salt as a Healthier Substitute in Lowering the Risk of Dietary Salt Induced Cognitive Insults in Experimental Rats

Authors: Keerthana P and Sarada Subramanian

Alzheimer’s disease (AD) belonging to the class of tauopathies, is a major cause of dementia globally. Observational studies in the aging population have reported that excessive dietary salt consump... Read more

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Research Article | 10.36959/734/383 Volume 5 Issue 1

Photobiomodulation Improves Memory in Mild Cognitive Impairment: Three Case Reports

Authors: Agnes S Chan, TszLok Lee, Sophia Sze and Michael R Hamblin

Three patients (mean age = 62) received 18-sessions of PBM stimulation twice per week for nine weeks. Each patient was assessed with Rey- Osterrieth Complex Figure Test (Rey-O testing visual memory) a... Read more

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Research Article | 10.36959/734/381 Volume 5 Issue 1

Drug Nanotargeting for Treating Vascular Dementia and Alzheimer's Disease

Authors: Joseph S. D'Arrigo, PhD

Microvascular endothelial dysfunction precedes, often by decades, the cognitive decline associated with Alzheimer's disease. Hence, preservation of a healthy cerebrovascular endothelium can be an impo... Read more

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Research Article | 10.36959/734/380 Volume 4 Issue 1

Ameliorative Effects of Intranasal AntagomiR-125b in AD

Authors: Chun Xiao and Neelima Chauhan

Alzheimer's disease (AD) is a global public health crisis. Currently, there are no treatments to prevent or halt the disease. Given the precedence of chronic neuroinflammation in triggering AD-like ne... Read more

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Research Article | 10.36959/734/379 Volume 4 Issue 1

Phospho-Tau Antibody Delivery Using Virus-Like Nanoparticles as Carriers Enhances Spatial Memory Functions in Tauopathy Model Rats

Authors: Susheel Kumar Joseph, Vishnuvardhan, C Sushmitha, Usha Natraj, Handanahal Subbarao Savithri, Sarada Subramanian

Anti-tau immunotherapies targeting phospho-epitopes have shown promising outcome in pre-clinical studies, although, with certain limitations in terms of mode of antibody delivery and concentration of ... Read more

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Research Article | 10.36959/734/378 Volume 4 Issue 1

Differential Inhibition of E-S Potentiation and Long-term Potentiation by Cell-Derived and Arctic Amyloid Beta

Authors: Adrienne L Orr, Jason K Clark and Daniel V Madison

Soluble oligomers of amyloid-beta peptide (Abeta) have been implicated in the onset of memory deficits in Alzheimer’s disease, perhaps due to their reported ability to impair long-term potentiation ... Read more

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Research Article | 10.36959/734/377 Volume 4 Issue 1

A Novel Concept is Needed for Combating Alzheimer’s Disease and NeuroHIV

Authors: Xiu-Ti Hu

Both Alzheimer’s disease (AD) and HIV-associated neurocognitive disorders (HAND) could progress to dementia, a severe consequence of neurodegenerative diseases. Cumulating evidence suggests that the... Read more

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Research Article | 10.36959/734/375 Volume 3 Issue 1

Gender Difference in Behavioral and Psychological Symptoms of Alzheimer's Disease

Authors: MU Nan, WU Huawang, MA Ping, RAO Dongping, YU Junchang, Huang Qiaoting, TANG Mouni, ZHANG Ruoxi and PAN Jiyang

Behavioral and psychological symptoms of dementia (BPSD) are important clinical manifestations of Alzheimer's Disease (AD), which may occur at the early stage or throughout the entire course of dement... Read more

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RESEARCH ARTICLE | 10.36959/734/374 Volume 2 Issue 1

Architectural Arrangement of Neurons as Part of the Functional Unit of the Central Nervous System

Authors: Allen J Orehek, Jose Rafael Iglesias-Rozas and Manuel Garrosa

An understanding of the cellular structural relationships in human brain tissue will allow for improved appreciation of the functional importance. A model of the functional unit brings together the im... Read more

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Research Article | 10.36959/734/373 Volume 1 Issue 2

Diagnostic Value of 123-I-MIBG Cardiac Scintigraphy for the Prediction of Conversion from Idiopathic REM Sleep Behavior Disorder to Dementia with Lewy Bodies, and the Differential Diagnosis of Neurodegenerative Diseases

Authors: Makiko Seto, Ruka Nakata, Takayuki Yuasa, Yoko Nakao, Katsuhiro Ichinose, Itsuro Tomita, Hideyo Satoh, Akira Satoh, Makoto Ochi and Mitsuhiro Tsujihata

Meta-iodobenzylguanidine (MIBG) is a physiologic analogue of noradrenaline, used to determine the location, integrity, and function of postganglionic noradrenergic neurons.... Read more

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Short Commentary | 10.36959/734/372 Volume 1 Issue 2

Machine Learning Detection of Cognitive Impairment in Primary Care

Authors: Boaz Levy, Samuel Gable, Elena Tsoy, Nurit Haspel, Brianna Wadler, Rand Wilcox, Courtney Hess, Jacqueline Hogan, Daniel Driscoll and Ardeshir Hashmi

Routine cognitive screenings in primary care settings can benefit patient care and preventive medicine in multiple ways; however, their integration to the protocol of physical exams, as a standard of ... Read more

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Short Commentary | 10.36959/734/371 Volume 1 Issue 1

From a "Eureka Insight" to a Novel Potential Therapeutic Target to Treat Alzheimer's Disease

Authors: Leandro Bueno Bergantin

It has been almost 4 years since we revealed the solution for the enigma of the so-called "calcium paradox". Our discovery of the involvement of Ca²⁺/cAMP signaling interaction in the regul... Read more

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Mini Review Article | 10.36959/734/370 Volume 1 Issue 1

What are the Main Pathogenetic Features of Vascular Cognitive Impairment?

Authors: Kurt A Jellinger

The term vascular cognitive impairment designates a heterogenous group of disorders ranging from mild cognitive impairment to full-blown dementia-vascular dementia-resulting from cerebrovascular lesi... Read more

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SHORT REVIEW ARTICLE | 10.36959/734/369 Volume 1 Issue 1

Non-Pharmacological Therapies in People with Alzheimer Dementia: Comparing Hand Massage and Conversational Approach in the Italian Context

Authors: Carmen Belacchi and Emanuela Capotosto

Non-pharmacological therapies have shown to have significant benefits in reducing behavioral psychological symptoms in people with dementia. This is a pilot study to compare the efficacy of two non-ph... Read more

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RESEARCH ARTICLE | 10.36959/734/368 Volume 1 Issue 1

Rensheng Shouwu Protects against Neuronal Injury by Inhibiting the Apoptosis Induced by Hypoxia and Reoxygenation

Authors: Jing Zhu, Li Wan, Yadong Zhu, Xu Yang, Yongming Cai, Wei-Jian Bei and Jiao Guo

Rensheng Shouwu Capsule (RSSW) is an approved and patented drug of Traditional Chinese Medicine that has been used for years to treat vascular dementia and neural syndrome related to cerebral-vascular... Read more

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Review Article | 10.36959/734/367 Volume 1 Issue 1

N-Acetylcysteine: A Natural Antidote for Alzheimer's Disease

Authors: Marcos Martínez-Banaclocha

Alzheimer's disease (AD) is the most devastating age-related dementia, which has no effective treatment. Since the pathological hallmarks of AD brains are Aβ plaques and intra-neuronal tau-containing... Read more

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BRIEF COMMENTARY | 10.36959/734/366 Volume 1 Issue 1

Parkinson's Disease: Old Concepts and New Challenges

Authors: Ramon Cacabelos

It is highly unlikely that James Parkinson (1755-1824), who first described the 'paralysis agitans' in his 'Assay on the Shaking Palsy' in 1817 (years later rebadged by Jean-Martin Charcot as Parkinso... Read more

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