Annals of Lung Cancer

 ISSN: 2643-5713

Annals of Lung Cancer Archives

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Research Article   |   10.36959/825/572 Volume 3 Issue 1

Dosimetric Implications of Number of Breathing Phases Used in the Definition of Internal Target Volume [ITV] in the Treatment of Non-Small Cell Lung Cancers Using Stereotactic Body Radiation Therapy (SBRT)

Authors: Von Darius Heard, Eftekhar Rajab Bolookat, Kate Martin, Jorge Gomez, Anurag K Singh and Harish Malhotra

Abstract: Determination of intrafraction motion in stereotactic body radiation therapy (SBRT) of non-small-cell lung cancer (NSCLC) usually involves generating an internal target volume (ITV) based on target segmentation in every one of the 10 phases of a 4-dimensional computed tomography (4DCT) dataset which increases dosimetry work load substantially. This study explores the feasibility of using a smaller number of phases to compile an ITV to get equivalent results.


Research Article   |   10.36959/825/581 Volume 3 Issue 1

Impact of an Onsite Endobronchial Ultrasound Program on the Time to Treatment of Cancer in Veterans

Authors: Van K Holden, MD, Stephanie Wappel, MD, Avelino C Verceles, MD, MS and Janaki Deepak MBBS

Abstract: Endobronchial ultrasound (EBUS) is commonly employed in the diagnostic evaluation of pulmonary nodules and for mediastinal staging of lung cancer. We hypothesized that the establishment of an onsite EBUS program would decrease the time to the diagnosis and treatment of detected malignancy in veterans seen in a dedicated pulmonary nodule clinic.


Editorial   |   10.36959/825/580 Volume 3 Issue 1

Nucleobindin-2 mRNA level is down regulated in KRAS-mutation lung cancer cell lines compared with EGFR/BRAF/KRAS wild-type lung cancer cell lines

Authors: Noriaki Sunaga, Hisao Imai, Junichi Okada, Eijiro Yamada, Shuichi Okada and Masanobu Yamada

Abstract: All participants understand that the information will be published anonymously, but that full anonymity cannot be guaranteed. We understand that the text and any pictures or videos published in the article will be freely available on the internet and may be seen by the general public. Pictures, videos, and text may also appear on other websites or in print, may be translated into other languages or used for commercial purposes.


Original Research   |   10.36959/825/579 Volume 3 Issue 1

Lobaplatin or Cisplatin Plus Etoposide for Treating Extensive Stage Small Cell Lung Cancer

Authors: Xin Zhou, Hongge Zhu, Yiyi Zhan and Chunling Liu

Abstract: The EL and EP groups did not differ substantial in objective response rate, hospital stay, or rate of leukocyte and platelet decrease. In the two groups, NSE (neuron-specific enolization enzyme) was reduced significantly after chemotherapy, but CEA (carcinoembryonic antigen) and CYFRA21 (cytokeratin 19 fragment) were not different between the two groups. In the EL group, the incidence of gastrointestinal reaction was reduced significantly and hospitalization cost was significantly increased.


Original Research Article   |   10.36959/825/578 Volume 3 Issue 1

Effect of Respirable Coal Mine Dust and Quartz on Lung Function Parameters of German Coalminers: A Longitudinal Study 1974-2004

Authors: Mei Yong, Laura Anderle, Hellmut Lenaerts, Rudolf Derwall and Peter Morfeld

Abstract: Longitudinal inception cohort study (1974-2004) on miners who started working underground at two coal mines in Germany between 1974 and 1979. From the continuous exposure monitoring, the numbers of the shifts exposed and the shift-average concentration are available, so that long-term average and cumulative concentration of respirable coal dust and quartz component can be derived. The effects of exposure on lung function parameters (FVC, FEV1, FEV1/FVC) were estimated with generalized estimation equation (GEE) models, after adjusting for anthropometric factors, smoking behaviour, and lung function measuring devices.


Original Article   |   10.36959/825/577 Volume 2 Issue 1

The Risk of Developing Coal Workers' Pneumoconiosis in a German Inception Cohort of Coal Miners of Ruhr Area - Results after 30 Years of Follow-up

Authors: M Yong, L Anderle, H Lenaerts, R Derwall, D Brand and P Morfeld

Abstract: Comprehensive dust control and health protection measures have been implemented to prevent coal workers' pneumoconiosis (CWP) in German collieries since several decades. The present study evaluates the risk of developing CWP related to exposure to respirable coal mine dust containing quartz.


Research Article   |   10.36959/825/576 Volume 1 Issue 1

Survival and Grades vs. Costs and Values of Nivolumab in Cancer; the Impact of PD-L1 Positivity

Authors: Helmy M Guirgis

Abstract: Nivolumab (Nivo) is a programmed death receptor-1 immune check point antibody widely used in cancer.


Research Article   |   10.36959/825/575 Volume 1 Issue 1

Survival and Values of the Immune Check Point Inhibitors in Non- Small-Cell Lung Cancer

Authors: Helmy M Guirgis

Abstract: The efficacy and safety of the Immune Check Point Inhibitors (ICPI) have been well documented. Their costs and values have received lesser attention.


Case Study   |   10.36959/825/574 Volume 1 Issue 1

Pseudoprogression in Non-Small Cell Lung Cancer Brain Metastases Attributable to the Anti-PD-1 Antibody Nivolumab

Authors: Sooraj John, Scott J Antonia, Trevor A Rose and Ben C Creelan

Abstract: Pseudoprogression is a challenging obstacle in the interpretation of therapeutic response to radiation and chemotherapies for metastatic brain lesions. Combination of stereotactic radio surgery post-treatment effects and anti-PD-1 antibody therapy may cause benign edematous enhancements in treated brain metastases which mimic tumor progression.


REVIEW ARTICLE   |   10.36959/825/573 Volume 1 Issue 1

Radiation Therapy in the Treatment of Small Cell Lung Cancer

Authors: Guler Yavas and Cagdas Yavas

Abstract: Small Cell Lung Cancer (SCLC) represents between 13-15% of all lung cancers; however is the fifth leading cause of cancer death worldwide. SCLC prognosis remains poor despite improvements in diagnosis and treatment over the last 30 years.


Research Article   |   10.36959/825/572 Volume 1 Issue 1

Is There an Increased Risk of Lung Cancer among the Chinese Silica Cohort? - The Influence of Occupational Confounders

Authors: Yi Sun and Frank Bochmann

Abstract: To evaluate a possible influence of confounding in risk estimation for lung cancer in relation to silica dust exposure, we re-analyze a recently published exposure-response relationship using a sub-cohort of Chinese tungsten miners which has no relevant occupational confounders.


Research Article   |   10.36959/825/571 Volume 1 Issue 1

A Quantitative Assessment of Lung Tumor Motion under Abdominal Compression using 4D-CT Imaging

Authors: Dennis Mohatt, Jorge Gomez and Harish K Malhotra

Abstract: Stereotactic Body Radiation Therapy (SBRT) has rapidly emerged as a curative procedure for early stage non-small cell lung cancer (NSCLC). The ablative hypo-fractionated radiation doses used with SBRT requires very small tumor margins, making tumor motion management very important to reduce the risk of long term morbidity.


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