Advances in Leukemia Research and Treatment

Research Article   |   10.36959/486/329 Volume 4 Issue 1

Comparison of Multiparameter Flow Cytometry and ClonoSEQ Studies for Precursor B-Lymphoblastic Leukemia Minimal Residual Disease Detection on Bone Marrow Samples

Authors: Nouran Momen, Joseph Tario, Kai Fu and You-Wen Qian

Minimal residual disease (MRD) detection for precursor B-lymphoblastic leukemia (B-ALL) has become standard of care. We retrospectively compared MRD evaluation using COG Multiparameteric flow cytometr... Read more

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Review Article   |   10.36959/486/328 Volume 3 Issue 1

Lymphocytosis with Large Granular Cells: Correlation between T-Cell Receptor Rearrangement and CD57 Expression

Authors: Jordi Juncà, Cristian Morales-Indiano, Lurdes Zamora, Marta Sitges, Minerva Raya, Sara Vergara and Marc Sorigué

The finding of large granular cells is relatively frequent when reviewing a blood smear for lymphocytosis (or for any other reason). The presence of these cells opens the question as if they are part ... Read more

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Brief Communication   |   10.36959/486/327 Volume 2 Issue 1

Efficient Ex Vivo Expansion of γδ T-Cells from AML Patients Requires Elimination of Circulating Leukemic Blasts

Authors: Ana C Parente-Pereira, Pramila Krishnamurthy, Lynsey M Whilding, Kyriaki Ioannou, Sara Ciprut, Victoria Potter, Ghulam J Mufti, Linda Barber, Farzin Farzaneh and John Maher

γδ T-cells play an important role in immune surveillance of acute myeloid leukemia (AML). The main circulating subtype expresses a Vγ9Vδ2 T-cell receptor and may be expanded ex vivo follo... Read more

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Case Report   |   10.36959/486/326 Volume 2 Issue 1

Preserving Platelet Count for a Diagnosed Patient with Acute Myeloid Leukemia on Hydroxychloroquine: A Case Report

Authors: Dina K. Farrag and Nagwa A. Sabri

A female patient (N.H.) 70-years-old, married and having two children was admitted to the oncology department El Agouza police Hospital, Egypt on July 2018, She was diagnosed with Relapsed Acute Myelo... Read more

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Case Report   |   10.36959/486/325 Volume 2 Issue 1

Role of Allogenic Bone Marrow Transplant in Patients with Paroxysmal Nocturnal Haemoglobinuria

Authors: Padmaja Lokireddy and Harshita Mydamn

37-yrs-old male patient presented with jaundice and passing cola colored urine. His blood parameters show Hb-6.5, WBC 6400, platelet count 2.6 lakhs, MCV-115, bilirubin-3.0, LDH-4980, Coombs test- neg... Read more

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CASE REPORT   |   10.36959/486/324 Volume 1 Issue 1

A Rare Involvement Region in a Patient with B-Cell Chronic Lymphocytic Leukemia: Skin

Authors: Tuba Bulduk, Hava Üsküdar Teke, Eda Tatlıpınar, Neslihan Andıç, Eren Gündüz and Deniz Arık

Skin involvement in Chronic Lymphocytic Leukemia (CLL) is rare and can present with very different lesions. Our case was a 51-year-old woman who had been followed without medication for 2 years with t... Read more

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Review Article   |   10.36959/486/323 Volume 1 Issue 1

High Doses of Vitamin C and Leukaemia: In Vitro Update

Authors: Domenico Mastrangelo, Lauretta Massai, Giuseppe Fioritoni and Francesco Lo Coco

Vitamin C (ascorbic acid) is an essential nutrient with a number of beneficial effects on the human body. Although the majority of mammals can synthesize their own Vitamin C, humans and a few other sp... Read more

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Letter   |   10.36959/486/322 Volume 1 Issue 1

Hematological Malignancy Diagnosed on Cytological Examination of Cavity Fluid: Pleural Effusion as First Manifestation of Acute Myeloid Leukemia

Authors: Cristiano Claudino Oliveira, Maria Luiza Cotrim Sartor de Oliveira and Maria Aparecida Custodio Domingues

Approximately 10% of pleural effusions have malignant etiology. Among malignancies, carcinomas represent more than three-quarters of the cases. Hematopoietic neoplasms correspond to 15% of the causes ... Read more

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