ISSN: 2642-4274
Home / Browse Journals & Books / Journal of Neurodegenerative Disorders / Archive / Volume 3, Issue 1
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Review Article Pages 89-100
Abstract: As a result of the global rise in life expectancy, dementia has become a major global health concern; it is considered to be one of the most burdensome conditions of later life. Despite 66% of older adults with dementia living in Low-and-Middle Income countries (LMIC), only 10% of dementia research has been conducted in these countries and more information is needed about research activity within LMIC to inform on global dementia research strategies.
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Case Presentation Pages 77-88
Abstract: The patient was given the diagnosis during evaluation at a comprehensive amyotrophic lateral sclerosis (ALS) center by the neurology team. During the year prior to the diagnosis of ALS the patient was evaluated by seven different neurologists over the course of the progressive disease. Coordinated evaluation refined the diagnosis to cryoglobulinemia causing a vasculitis that resulted in severe peripheral neuropathy.
Research Article Pages 65-76
Abstract: Brain edema due to the over expression of AQP4 is a major determinant for progression of neuronal insult during ischemic stroke. During brain pathology, both down regulation and up regulation of AQP4 expression is observed. However, AQP4 over expression is one of the main contributors of water imbalance occurring in the brain during ischemic stroke.
Review Article Pages 51-53
Abstract: The frequency of seizures as a first sign of the AD is probably underestimated. The physician should be aware that seizures of unknown origin among the elderly could be the first sign of the AD. Besides, if confirmed by wider series, it should be admitted the possibility of an atypical non-cognitive onset of the AD.
Research Article Pages 54-64
Abstract: It is possible that about 30% of all dementia is preventable by addressing many of the modifiable health and lifestyle risks important for overall physical health. Currently, people in the pre-dementia or very early dementia stage who are referred to Memory Assessment Services (MAS) in the UK receive minimal, if any, support and/or intervention. They are typically referred back to primary care until the full syndrome of dementia emerges. This represents a lost opportunity to modify the trajectory of the condition, intervene with disease modifying therapies (DMTs) when available, and delay the onset of a full dementia syndrome.
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