Translational Neuroscience Research and Reviews

Research Article   |   10.36959/817/526 Volume 3 Issue 1

Loss of Oligodendrocytes by Oxidative Phosphorylation Inhibitor Rotenone and its Reversal by Phenylbutyrate (PB) in Human Brain Developmental Organoid Model

Authors: David Freedman, PhD, Ewa K Stachowiak, PhD and Michal K Stachowiak, PhD

Brain oligodendrocytes have been shown to be particularly affected by hypoxia and mitochondrial insufficiency. To model their effects on human brain development, we exposed developing human iPSC deriv... Read more

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Research Article   |   10.36959/817/525 Volume 3 Issue 1

Loss of Oligodendrocytes in Mouse Model of Pyruvate Dehydrogenase Complex Deficiency and Partial Reversal by Phenylbutyrate Treatment

Authors: David Freedman, Ilona Klejbor, Saleh Mahmood, Mulchand S Patel, Michal K Stachowiak and Ewa K Stachowiak

Human pyruvate dehydrogenase complex (PDC) deficiency caused by mutations of the pyruvate dehydrogenase component (PDH) of the pyruvate dehydrogenase complex (PDC) is associated with the loss of myeli... Read more

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