Translational Neuroscience Research and Reviews

Research Article   |   10.36959/817/526 Volume 3 Issue 1

Loss of Oligodendrocytes by Oxidative Phosphorylation Inhibitor Rotenone and its Reversal by Phenylbutyrate (PB) in Human Brain Developmental Organoid Model

Authors: David Freedman, PhD, Ewa K Stachowiak, PhD and Michal K Stachowiak, PhD

Brain oligodendrocytes have been shown to be particularly affected by hypoxia and mitochondrial insufficiency. To model their effects on human brain development, we exposed developing human iPSC deriv... Read more

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Research Article   |   10.36959/817/525 Volume 3 Issue 1

Loss of Oligodendrocytes in Mouse Model of Pyruvate Dehydrogenase Complex Deficiency and Partial Reversal by Phenylbutyrate Treatment

Authors: David Freedman, Ilona Klejbor, Saleh Mahmood, Mulchand S Patel, Michal K Stachowiak and Ewa K Stachowiak

Human pyruvate dehydrogenase complex (PDC) deficiency caused by mutations of the pyruvate dehydrogenase component (PDH) of the pyruvate dehydrogenase complex (PDC) is associated with the loss of myeli... Read more

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Research Article   |   10.36959/817/524 Volume 2 Issue 1

Effects of Non-Focused ELF-EMF Treatment on EEG: Preliminary Study

Authors: Alessandro Greco, MD and Alberto Garoli, MD

The central nervous system (CNS) is known to be sensitive to focused magnetic stimulation, which is now used routinely for the treatment of various disorders. Extremely Low Frequency Electro Magnetic... Read more

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Research Article   |   10.36959/817/523 Volume 2 Issue 1

Transhemispheric Diaschisis after Unilateral Focal Cerebral Ischemia Reperfusion: A Longitudinal Voxel-Based Study by MRI

Authors: Saeid Taheri, PhD, Jin Yu, MD, Hong Zhu, MD, Honglian Shi, PhD and Mark S Kindy, PhD

It is now little doubt that the insult of ischemia/reperfusion (I/R) impacts cerebral blood flow (CBF) not only within the lesion area but also in the area beyond the lesion territory. Focal I/R has ... Read more

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Review Article   |   10.36959/817/522 Volume 2 Issue 1

Common Substrates of Medication-Resistant Temporal Lobe Epilepsy: Hippocampal Sclerosis, Focal Cortical Dysplasia, and Combined Pathologies

Authors: Brandon M Korman, Ph.D, Psy D

Temporal lobe epilepsy (TLE) is an etiologically heterogeneous syndrome that constitutes the largest proportion of refractory partial epilepsies. The most common substrates of TLE include focal cortic... Read more

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Review Article   |   10.36959/817/521 Volume 2 Issue 1

Neuroprotective and Anti-Inflammatory Properties from the Bioactive Constituents of Myracrodruon Urundeuva, a Brazilian Medicinal Species

Authors: Glauce Socorro de Barros Viana and Iana Bantim Felício Calou

Myracrodruon urundeuva Fr. All. (Anacardiaceae) is largely used, by the Northeast Brazil population, for its anti-inflammatory actions, already confirmed by experimental studies. In addition, this med... Read more

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