Journal of Cervical Cancer Research

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Table of Content: Volume 1, Issue 1

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Research Article Pages 6-9

Utility of P16 and Ki-67 Expression in Cervical Biopsy with Cervical Intraepithelial Neoplasia 2 to Predict Diagnosis in Subsequent Cervical Excision Specimen

Authors: Alan Marcus, Zhenglong Wang and Khushbakhat Mittal

Abstract: Treatment guidelines differ for young women with Cervical Intraepithelial Neoplasia (CIN) 2 lesions on biopsy depending on their desire for future pregnancy. Therefore, we investigated the utility of using P16 and Ki-67 immunohistochemical stains on cervical biopsies diagnosed with CIN 2 to determine the outcome on subsequent excisional specimens. The study included 22 patients, with a mean age of 34 years and an age range from 20 to 51 years. Positive staining for p16 was identified in 21/22 patients.

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Case Report Pages 1-5

Neoadjuvant Chemotherapy with Paclitaxel and Nedaplatin plus Radical Surgery in Cervical Cancer during Pregnancy: A Case Report and Review of the Literature

Authors: Fei Xu, Gang Chen, Ling Chen, Hai Yan Weng, Kunli Su, Xuefen Zhang, Yong Cheng, Dabao Wu and Ying Zhou

Abstract: A 36-year-old Han Chinese female with cervical cancer staged as IB1 at the gestational age of 30 + 3 weeks was referred to our department. The patient and the family refused to term pregnancy and wanted pregnancy-preserving management, she was treated by neoadjuvant chemotherapy with paclitaxel 230 mg plus nedaplatin 120 mg first, and caesarean section; radical hysterectomy and pelvic lymph node dissection were performed three weeks later. Based on the pathology report, the patient underwent further radiotherapy, and the neonate was healthy.

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