Insights of Biomedical Research

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Review Article Pages 139-148

Chemical and Physiological Change from Calcium Carbonate to Calcium Phosphate in Skeletal Structures

Authors: Dee H. Wu, PhD, Caroline Preskitt, BS and Carolyn Gresham-Fiegel, MPH, MS

Abstract: The substrates that comprise skeletal structures have evolved over more than 480 million years. We review chemical and physiological factors that may have driven the evolutionary process from an original calcium carbonate composition of skeletal structures to the calcium phosphate-based bone physiology that we observe in vertebrates today. A review of this topic is not without challenges, however.

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