Advances in Translational Medicine Research

Research Article   |   10.36959/457/578 Volume 3 Issue 1

Stratifying Individuals at Risk of Prostate Cancer Using a Novel Biomarker-Based Predictive Algorithm

Authors: Mary Jo Kurth, Joanne Watt, Laura Mooney, Allister Irvine, John V. Lamont, Peter Fitzgerald and Mark W. Ruddock

In the United Kingdom (UK), prostate cancer (PCa) is a significant health concern, with over 50,000 new cases reported annually. Prostate cancer now accounts for almost 26% of all new cancers in ... Read more

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Review Article   |   10.36959/457/577 Volume 2 Issue 1

Drowning in Data: Early Responses of Renal Cortical Collecting Duct Cells to Lithium

Authors: John Leader, Jennifer Bedford and Robert Walker

It is now more than fifty years since Burg made a signal advance in the study of renal physiology by reporting a method of isolating and perfusing tubules from selected regions of the kidney. Prior to... Read more

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Research Article   |   10.36959/457/576 Volume 1 Issue 1

Enzyme Activity of 3ß-HSD and 11ß-HSD as Important Indicators of Steroid Bio-Synthesis and Inactivation in Preterm Infants

Authors: Jan De Laffolie, Lars Kastner, Michaela F Hartmann, Stefan A Wudy, Birgit Kampschulte, Bianca Grofer, Rolf-Hasso Bodeker and Matthias Heckmann

The fetus lacks 3ß-hydroxysteroiddehydrogenase (3ß-HSD) activity until the last trimenon (requiring placental progesterone) and active cortisol concentration is regulated by synthesis through 11ß-h... Read more

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Research Article   |   10.36959/457/575 Volume 1 Issue 1

Cognitive Behavioral Tests May Predict Eye Affection in High-Fat Diet Induced Pre-Obese Mice: Implications for Diabetic Retinopathy

Authors: Paul F Seke Etet

Indicators of progression to diabetic retinopathy (DR) are needed in type 2 diabetes mellitus (T2DM) obese patients. We assessed the predictive power of cognitive function indicators for eye involveme... Read more

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Research Article   |   10.36959/457/574 Volume 1 Issue 1

Inhibition of the Sonic Hedgehog Pathway by Cyclopamine or GLI1 siRNA Reduces In Vivo Tumorigenesis of Human Medulloblastoma Cells Xenotransplanted to Immunodeficient Nude Mice

Authors: Javier de la Rosa, Monica Sanchez, Monica Enguita-German, Ricardo Garcia-Lopez, Paula Schiapparelli, Mehdi H Shahi, Barbara Melendez, Juan A Rey, Miguel A Idoate and Javier S Castresana

Medulloblastoma is an aggressive tumor; grade IV of the WHO classification that develops in the cerebellum, mostly linked to infancy and adolescence. It can be classified histologically and molecularl... Read more

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