Professor
Department of Pathology and Laboratory Medicine
Lewis Katz School of Medicine
Temple University School of Medicine
United States of America
Prof. Nahum j Duker is Professor in Department of Pathology and Laboratory Medicine and the Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, USA. His Research Interests includes A paradigm for etiogenesis of neurodegenerative disorders has emerged which implicates unrepaired oxidative DNA damage in neuron cell death via apoptosis. Evidence indicates unrepaired DNA purine dimers to be the molecular link between intracerebral deposition of amyloid-ß protein [Aß] and neural cell loss in Alzheimer's disease. Aß reacts with the receptor for advanced glycation end products [RAGE], resulting in generation of free radicals; these result in oxidative DNA damages.
