Clinical Journal of HIV & AIDS

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Table of Content: Volume 2, Issue 1

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Research Article Pages 28-35

Factors Associated with Time to Virological Failure among HIV Patients on First Line Antiretroviral at Kenyatta National Hospital Comprehensive Care Centre, Nairobi Kenya

Authors: Mutabari David, Hillary Kipruto, Peter Muiruri and Ann Wang'ombe

Abstract: Kenya has recorded a high burden of HIV with 1.5 million HIV + persons by 2015. With the adoption of 2016 ART guideline in Kenya all PLHIV now qualify for antiretroviral (ART) irrespective of WHO clinical stage, cd4 count, age gender, pregnancy status, co-infected status thus increasing the number of patients likely to develop resistance. Once a patient develops resistance to first line, they are put on second line ART regimen which is more expensive and less tolerable. This study seeks to establish the duration of time patients put on first line ART take before developing virological failure and factors influencing it as a step towards guiding the management in adequate planning and budget allocation for management of these patients.

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CASE REPORT Pages 26-27

Coadministration of Divalent Cation Mineral Supplements Causes cART Virologic Failure and HIV Mutagenesis: A Case Study

Authors: Thomas M Forst and Warren L Dinges

Abstract: Integrase strand transfer inhibitors (INSTIs) are an important component of modern combined antiretroviral therapy (cART). The mechanism of inhibition for these antivirals is dependent on magnesium ion binding during attempted HIV-1 replication.

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