ISSN: 2578-6490
Professor
Pharmaceutical Sciences
Tokushima Bunri University
Tokushima
Japan
Dr. Yoichi Matsunaga started his research carrier in Immunotherapy of hepatocellular carcinoma in Kochi University, Department of Digestive disease, obtained ph.D by "The resident lymphocytes in the liver" in 1990. In the process, he recognized the significance of antigen processing and presentation in immunology and collaborated with Dr Katunuma's Lab at the Institute of Enzymology in Tokushima University, then focus on Cathepsin B in foreign antigen processing (1990-1995). In 1990's, Prion disease was a topic in life science. Prion is the transmissible proteinous agents, resistant to proteases, it is very impressive as pathogen of neurodegenerative disease. By chance he got an opportunity to study "prion" in Dr Prusiner's Lab at UCSF as a postodoctoral fellow (1996-2000). After coming back to Japan, he started the extension of Prion, "Amyloid-beta in Alzheimer's disease" as his research interests. Since 2000, he focused on surrounding factors preceding amyloid-beta aggregation, related to conformational changes.
