Advances in Translational Medicine Research

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Table of Content: Volume 1, Issue 1

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Research Article Pages 16-22

Enzyme Activity of 3ß-HSD and 11ß-HSD as Important Indicators of Steroid Bio-Synthesis and Inactivation in Preterm Infants

Authors: Jan De Laffolie, Lars Kastner, Michaela F Hartmann, Stefan A Wudy, Birgit Kampschulte, Bianca Grofer, Rolf-Hasso Bodeker and Matthias Heckmann

Abstract: The fetus lacks 3ß-hydroxysteroiddehydrogenase (3ß-HSD) activity until the last trimenon (requiring placental progesterone) and active cortisol concentration is regulated by synthesis through 11ß-hydroxylase and inactivation by 11ß-hydroxysteroiddehydrogenase (11ß-HSD).

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Research Article Pages 6-15

Cognitive Behavioral Tests May Predict Eye Affection in High-Fat Diet Induced Pre-Obese Mice: Implications for Diabetic Retinopathy

Authors: Paul F Seke Etet

Abstract: Indicators of progression to diabetic retinopathy (DR) are needed in type 2 diabetes mellitus (T2DM) obese patients. We assessed the predictive power of cognitive function indicators for eye involvement in high fat diet (HFD)-induced pre-obese mice.

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Research Article Pages 1-5

Inhibition of the Sonic Hedgehog Pathway by Cyclopamine or GLI1 siRNA Reduces In Vivo Tumorigenesis of Human Medulloblastoma Cells Xenotransplanted to Immunodeficient Nude Mice

Authors: Javier de la Rosa, Monica Sanchez, Monica Enguita-German, Ricardo Garcia-Lopez, Paula Schiapparelli, Mehdi H Shahi, Barbara Melendez, Juan A Rey, Miguel A Idoate and Javier S Castresana

Abstract: Medulloblastoma is an aggressive tumor; grade IV of the WHO classification that develops in the cerebellum, mostly linked to infancy and adolescence. It can be classified histologically and molecularly in different subtypes.

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