Annals of Sleep Medicine

Annals of Sleep Medicine

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Table of Content: Volume 4, Issue 1

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Original Article Pages 43-61

Characteristics of Obstructive Sleep Apnea in Obese Minipigs

Authors: Zi-Jun Liu, Mohamed Yehia Abdelfattah, Meng-Zhao Deng and Edward M. Weaver

Abstract: The report comprehensively evaluated physiologic, anatomic, tissue, functional, and modeled air flow characteristics of obstructive sleep apnea (OSA) in four obese and three non-obese control minipigs (8.5-months to 6.5-years. The approaches included: 1) Sleep monitoring to identify OSA during natural and sedated sleep; 2) Sonometric technique to quantify 3D respiratory deformational changes of the tongue base (TB) and soft palate (SF); 3) Fat-weighted MRI and ultrasound elastography (EUS) to calculatepercentage of fat composition and tissue strain in TB, SF, and pharyngeal wall; 4) Sleep videofluoroscopy (SVF) to trace respiratory movements of SF and TB; 5) MRI to quantify 2D and 3D oropharyngeal airway dimensions and volumes along with respiratory airflow measurements; and 6) Computational flow dynamic (CFD) to model airflow dynamics.

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