Insights of Pharmacology and Pharmaceutical Science

Case Report Pages 18-26

Stress-Induced Down-Regulation of Nitric Oxide Synthase in the Rat Heart

Authors: Viviane Caceres, Ana Elisa Teófilo S de Carvalho, Daniela Ortolani, Luana Silva Rodrigues, Lila Missae Oyama and Regina CeliaSpadari

Abstract: beta3-adrenoceptor (beta3-AR) is expressed in a smaller proportion than beta1-AR and beta2-AR in the hearts of rats and humans and is activated in the presence of high concentrations of catecholamines. In the myocardium, beta3- ARs couple to G inhibitory protein that activates nitric oxide synthases (NOS), thus increasing nitric oxide production that reduces inotropism. Beta2-ARs and beta1-ARs remodeling was described in failing and senescent human and rodent

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