Clinical Pediatrics and Research

Letter to the Editor Pages 98

Influenza: To Treat or Not To Treat

Authors: Henry J Simon, BS, Michael W Simon, MD, PhD

Abstract: The current recommendation is unless an individual is at high risk for influenza complication, to not start anti-influenza medication if delayed more than 48 hours after onset of symptoms. This recommendation was the result of clinical investigation design and data submitted to the FDA for licensure, routine shortages of influenza medications and a concern of evolving antiviral resistance. After 24 to 72 hours of antiviral treatment, virus replication has been slowed if not stopped.4 Individuals with untreated influenza may be contagious and spread the virus for 7 days or longer if high risk after the onset of symptoms

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