Otolaryngology Research and Reviews

 ISSN: 2578-6369


  John E Nathan
  Northwestern University Feinberg School of Medicine, USA

Otolaryngology Research and Reviews

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Case Report Pages 55-59

Malignant Peripheral Nerve Sheath Tumor with Loss of SMARCB1 and Diffuse S1000 Expression Arising in a Trigeminal Nerve Schwannoma

Authors: Melissa Zheng, BA, Zhonghua Li, MD, PhD, Carolyn L Mulvey, MD, Arthur P Staddon, MD, David W Kennedy, MD and Virginia A LiVolsi, MD

Abstract: Malignant peripheral nerve sheath tumors (MPNSTs) are rare sarcomas of the nerve sheath that infrequently involve the head and neck region. The few reports of MPNSTs arising from benign schwannoma precursors typically exhibit epithelioid morphology. We describe an exceptional case of a conventional MPNST arising in a benign trigeminal nerve schwannoma of a 21-year-old man without neurofibromatosis or familial schwannomatosis. Histologically

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