Journal of Neurodegenerative Disorders

Review Article Pages 143-153

Parkinson's Disease, Diet and Gut Microbiota Alterations

Authors: David Armando Guach-Hevia, MD

Abstract: A wide research was made about the gut microbiota brain axis and its implications in metabolic, endocrine, intestinal and neurological issues. Dysregulation of the gut microbiota brain axis due to gastrointestinal alterations has been recently associated with the pathogenesis of several neurodegenerative diseases, including Parkinsonism, supporting the hypothesis that the pathological process is spread from the gut to the brain. Diet induced metabolic disorders, through immunological, bacterial and intestinal parameters variations may induce systemic inflammation, stimulating the alpha-synuclein misfolding and the dopaminergic impairment seen in patients with shakiness paralysis' risk, favoring the Parkinsonism genesis and progression.

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