ISSN: 2642-4274
Home / Browse Journals & Books / Journal of Neurodegenerative Disorders / Archive / Volume 5, Issue 1
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Editorial Pages 141-142
Abstract: Neurodegeneration with brain iron accumulation (NBIA) comprises a group of rare but devastating inherited neurological diseases with unifying features of gradual cognitive and motor decline, and progressive degeneration of basal ganglia, globus pallidus, and reticular part of substantia nigra, produced by brain iron accumulation
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Review Article Pages 133-140
Abstract: Alzheimer's Disease (AD), Parkinson's Disease (PD), and Dementia are all age-related neurodegenerative diseases. In the US, AD victims are increasing every year from 5.5 million in 2018 to 13.8 million by 2050. PD patient are calculated to increase from 7K to 1 million by 2030. Results from accumulation of extracellular amyloid-β (Aβ) peptide and deposition of intracellular tau aggregated tangles. The prognosis of AD and PD both is the onset of Dementia, which causes memory
Case Presentation Pages 129-132
Abstract: Frontotemporal lobe degeneration (FTLD) comprises a spectrum of clinical syndromes that includes multiple neurodegenerative disorders with different neuropathological pathways that lead to a common frontal and temporal lobe degeneration and share a similar complex phenotype, consisting of early-onset dementia with progressive deficits in behavior, language, motor and executive functions. Behavioral variant of frontotemporal lobe degeneration (bvFTLD) usually presents with disinhibition or apathy, loss of empathy, perseverative/compulsive behaviors, hyperorality and executive dysfunction, thus mimicking many psychiatric disorders, such as schizophrenia, schizoaffective disorder, major depressive disorder, bipolar disorder, obsessivecompulsive disorder or personality disorders, as there is a significant symptomatic overlap with these entities
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