Journal of Neurodegenerative Disorders

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Table of Content: Volume 4, Issue 1

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Research Article Pages 122-128

The Experience of Parkinson’s Disease in Hai District, Tanzania

Authors: Natasha Fothergill-Misbah, Catherine Dotchin, John Kisima, Kate Hampshire, and Richard Walker

Abstract: Parkinson’s disease (PD) is a debilitating neurological disease that can result in a reduced quality of life for people with Parkinson’s disease (PwP) and their families. The incidence of PD continues to increase as the global population ages, as is being experienced in Tanzania and much of sub-Saharan Africa, yet healthcare systems are under-developed and not prepared to manage the burden posed by chronic conditions.

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Review Article Pages 113-121

Role and Molecular Mechanisms of Lysosomes and Cathepsins in Neuropathology and Aging: New Insights

Authors: Muhammad Babar Khawar, Naz Fatima, Muddasir Hassan Abbasi, Nadeem Sheikh, Hafiza Nabeela Amaan, Rabia Mehmood, Maryam Mukhtar, Amin Arif, Zaira Ahmad, Zerwa Siddique, Adil Farooq and Tahaa Saeed

Abstract: Lysosomes are the major catabolic entities that target a large number of biomolecules and pathogens as well. These cytoplasmic organelles play a substantial role in maintaining homeostasis with the aid of a vast assortment of its cathepsins. Cathepsins and its variants are reported to be involved in multiple physiological activities including apoptosis, coagulation, cell proliferation, immunity, and digestion, etc. These cathepsins are responsible for apoptosis leading to neuropathological changes and aging.

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Systematic Review Pages 101-112

Effectiveness of Repetitive Transcranial Magnetic Stimulation on Freezing of Gait in Parkinson's Disease Patients: A Systematic Review of the Literature

Authors: Wael Ibrahim, MD

Abstract: Episodes of FOG is often a debilitating event occurring in patients with Parkinson's disease (PD). TMS has been studies as a treatment options for a number of neuropsychiatric disorders including depression, PD, dystonia, and epilepsy.

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