Insights of Neuro Oncology

 ISSN: 2643-6094

Insights of Neuro Oncology

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Table of Content: Volume 3, Issue 1

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Research Article Pages 43-47

Tamoxifen for Recurrent High-Grade Glioma: A Retrospective Study

Authors: De Roxas RC, Omene E, Young K, Coppens R, Fulton DS and Easaw JC

Abstract: The management of recurrence in patients with high-grade glioma remains controversial. The lack of clear molecular targets to guide systemic therapy for patients has resulted in the use of various systemic agents with modest efficacy but with significant side effects. Tamoxifen has been used in our centre with some success and excellent tolerability.

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Research Article Pages 31-42

Local Drug Delivery by Fibrin Glue for Glioma Treatment: Enhancing Drug Efficacy by Photochemical Internalization (PCI)

Authors: Lina Nguyen, Diane Shin, Mai T Le, Eric O Potma, Nehal Idris, Jimmy Nguyen Le, Julie Johnson, Qian Peng, Kristian Berg and Henry Hirschberg

Abstract: Localized methods of drug delivery, such as controlled drug release from fibrin glue (FG), has the potential of improving the efficacy of chemotherapy for brain tumors by bypassing the blood brain barrier. Photochemical internalization (PCI) of bleomycin (BLM) and doxorubicin (DOX) has been shown to enhance the cytosolic delivery of drugs in localized site and temporal specific manner.

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Original Article Pages 27-30

Immunohistochemical and Biomolecular Characteristics of Craniopharyngiomas: A Single Institution Experience from Southern Italy

Authors: A Ieni, R Cardia, G Giuffrè and G Tuccari

Abstract: In the present paper, The Authors discuss the histological and immunohistochemical aspects observed in a casuistry of craniopharyngiomas (CP), identifying not only subtypes (papillary or adamantinomatous), but also their proliferative activity and molecular pathways. For this purpose, A series of thirty-seven was retrieved during the last decade (2007-2017) from files of our pathology department; there were 21 female and 16 male patients (age range 5-75 years, mean age 43.48), but 7 cases were recorded in childhood. A prevalent adamantinomatous pattern (ACP) (34 cases) was encountered, while only 3 exhibited papillary variant (PCP).

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