Annals of Nephrology

Research Article Pages 39-46

A Pilot Study Comparing Uric Acid and Biomarkers of Renal Injury and Inflammation in Pediatric Sickle Cell Disease at Vaso-Occlusive Crisis and Steady State

Authors: Kaspar CDW, Ghosh SS, Lo M, McClish D, Sisler I, Newlin J, Feig DI and Smith W

Abstract: Hyperuricemia hastens the decline of renal function in chronic kidney disease and activates the pro-inflammatory Nlrp3 inflammasome. Studies from the 1970s posited that high rates of hyperuricemia seen in sickle cell anemia (SCA) patients were due to high nucleotide production resulting from a chronic ischemia activated bone marrow. As such, serum uric acid (UA) levels may vary between states of vaso-occlusion. It is currently unknown whether serum UA is variable over time, nor the effect of hyperuricemia on renal injury and inflammation in SCA.

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