Aspects of Nanotechnology

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Table of Content: Volume 1, Issue 1

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Research Article Pages 52-60

Polymorphism, Crystallinity and Hydrophilic-Lipophilic Balance (HLB) of Cetearyl Alcohol and Cetyl Alcohol as Raw Materials for Solid Lipid Nanoparticles (SLN)

Authors: Flavia Diniz, Conrado Marques, Thallysson Carvalho Barbosa, Daniele Martins, Luciana Nalone, Salvana Costa, Marco V Chaud, Classius F da Silva, Eliana B Souto, Raquel de Melo Barbosa and Patrícia Severino

Abstract: The use of SLN as carriers for drugs for topical administration has been highlighted due to advantages over chemical degradation protection of the formulation of the active, hydration (occlusion of the stratum corneum) and enhanced penetration of drugs in the different layers, and promote the sustained release with reduced systemic absorption and possess properties of photoprotection against UV light.

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Research Article Pages 40-51

A New Approach for Utilization of Modified Epicoccum Nigrum Biomass by Ferric Chloride Nanoparticles for Biosorption of Thorium

Authors: Shimaa S Hussien, Osman A Desouky and Mohamed Elkattan

Abstract: Biosorption of thorium by Epicoccum nigrum biomass was determined at varying experimental conditions using a batch technique. High biosorption efficiency was observed for dead biomass 500 mg/50 mL of E. nigrum within 60 min of contact, at pH 6.8, temperature of 30 ℃ and agitation speed of 150 rpm with 150 mg/L as initial thorium concentration. Scanning electron microscope (SEM) equipped with electron dispersive X-ray (EDX) was used for characterization of the biosorbent agent after and before biosorption process to identify composition of elements of the dead biomass after and before biosorption of thorium.

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Research Article Pages 32-39

Targeting Ability of c(RGDyK)-Functionalized Nanoparticles is Inhibited by Protein Coronas

Authors: Shanshan Zhu, Yang Liu, Changhui Wang, Kai Ye, Ping Wang, Gang Huang and Dannong He

Abstract: Nanoparticles functionalized with targeting ligands have been proposed as effective carriers for the selective delivery of diagnostic or therapeutic reagents to desired locations in the body. However protein coronas formed on the surface of such functionalized nanoparticles may affect their targeting efficiency when introduced into physiological environment.

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Research Article Pages 20-31

Surface Density of Charged Functional Groups on Quantum Dots Determines Their Intracellular Compartmentalization and Biocompatibility

Authors: Yvonne Williams, Alyona Sukhanova, Jennifer Conroy, Bashir Mohamed, Vladimir Oleinikov, Mikhail Artemyev, Ciaran M Maguire, Igor Nabiev and Yuri Volkov

Abstract: Quantum Dots (QD) have a broad potential in the development of imaging, diagnostic and drug-delivery tools. Due to the homeostatic composition of biological systems, any charge on the surface of QD may influence penetration through the cell and organelle membranes, thus changing their cytotoxic effects.

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Review Article Pages 1-9

Evaluation of the Potential Genotoxicity of Quantum Dots. A Review

Authors: Esref Demir and Vincent Castranova

Abstract: The Quantum Dots (QDs) are widely used in different biological and biomedical applications due to their unique optical, electronic, physicochemical properties. Different QDs recently have been used for tumour imagining, gene therapy, and drug delivery. They are developed for numerous applications.

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