Annals of Lung Cancer

 ISSN: 2643-5713

Annals of Lung Cancer

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Table of Content: Volume 3, Issue 1

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Case Report Pages 90-93

Endobronchial Sarcoma: A Case Report and Review of Literature

Authors: Anu Menon, MD, Varun Shah, MD, Adnan Hasanovic, MD, Viera Lakticova, MD

Abstract: Pulmonary sarcomatoid carcinomas (PSCs) are poorly differentiated non-small cell lung carcinomas (NSCLCs) that, loosely, consist of a sarcoma-like element and/or a sarcomatous component - they represent one of the rarest sub-types of lung tumors. Pre-operative analysis with bronchoscopic biopsy is often an underrepresentation of tissue structure in its entirety, leading to hindrance in definitive diagnosis. Here we present the case of a male presenting with progressive dyspnea, ultimately diagnosed with a pulmonary sarcomatoid tumor with extensive local infiltration on bronchoscopy.

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Review Article Pages 84-89

Prognostic Impact of Ablative Therapy in Oligometastatic Non- Small-Cell Lung Cancer (NSCLC) with Unresectable Primary Tumor

Authors: Javier Garde-Noguera, Sara Marin-Liebana, Carmen Salvador-Coloma, José Garcia-Sánchez, Beatriz Honrubia-Peris, Corina Escoin, Nuria Piera, Oscar Juan-Vidal

Abstract: Patients with Oligometastatic (OM) non-small-cell lung cancer (NSCLC) (≤ 3 metastases) might benefit from radical ablative treatment of both primary tumor and metastases. However, the role of ablative therapy in OM patients with locally advance primary tumor has not been evaluated.

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Research Article Pages 75-83

Dosimetric Implications of Number of Breathing Phases Used in the Definition of Internal Target Volume [ITV] in the Treatment of Non-Small Cell Lung Cancers Using Stereotactic Body Radiation Therapy (SBRT)

Authors: Von Darius Heard, Eftekhar Rajab Bolookat, Kate Martin, Jorge Gomez, Anurag K Singh and Harish Malhotra

Abstract: Determination of intrafraction motion in stereotactic body radiation therapy (SBRT) of non-small-cell lung cancer (NSCLC) usually involves generating an internal target volume (ITV) based on target segmentation in every one of the 10 phases of a 4-dimensional computed tomography (4DCT) dataset which increases dosimetry work load substantially. This study explores the feasibility of using a smaller number of phases to compile an ITV to get equivalent results.

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Research Article Pages 66-74

Impact of an Onsite Endobronchial Ultrasound Program on the Time to Treatment of Cancer in Veterans

Authors: Van K Holden, MD, Stephanie Wappel, MD, Avelino C Verceles, MD, MS and Janaki Deepak MBBS

Abstract: Endobronchial ultrasound (EBUS) is commonly employed in the diagnostic evaluation of pulmonary nodules and for mediastinal staging of lung cancer. We hypothesized that the establishment of an onsite EBUS program would decrease the time to the diagnosis and treatment of detected malignancy in veterans seen in a dedicated pulmonary nodule clinic.

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Editorial Pages 64-65

Nucleobindin-2 mRNA level is down regulated in KRAS-mutation lung cancer cell lines compared with EGFR/BRAF/KRAS wild-type lung cancer cell lines

Authors: Noriaki Sunaga, Hisao Imai, Junichi Okada, Eijiro Yamada, Shuichi Okada and Masanobu Yamada

Abstract: All participants understand that the information will be published anonymously, but that full anonymity cannot be guaranteed. We understand that the text and any pictures or videos published in the article will be freely available on the internet and may be seen by the general public. Pictures, videos, and text may also appear on other websites or in print, may be translated into other languages or used for commercial purposes.

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Original Research Pages 60-63

Lobaplatin or Cisplatin Plus Etoposide for Treating Extensive Stage Small Cell Lung Cancer

Authors: Xin Zhou, Hongge Zhu, Yiyi Zhan and Chunling Liu

Abstract: The EL and EP groups did not differ substantial in objective response rate, hospital stay, or rate of leukocyte and platelet decrease. In the two groups, NSE (neuron-specific enolization enzyme) was reduced significantly after chemotherapy, but CEA (carcinoembryonic antigen) and CYFRA21 (cytokeratin 19 fragment) were not different between the two groups. In the EL group, the incidence of gastrointestinal reaction was reduced significantly and hospitalization cost was significantly increased.

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Original Research Article Pages 48-59

Effect of Respirable Coal Mine Dust and Quartz on Lung Function Parameters of German Coalminers: A Longitudinal Study 1974-2004

Authors: Mei Yong, Laura Anderle, Hellmut Lenaerts, Rudolf Derwall and Peter Morfeld

Abstract: Longitudinal inception cohort study (1974-2004) on miners who started working underground at two coal mines in Germany between 1974 and 1979. From the continuous exposure monitoring, the numbers of the shifts exposed and the shift-average concentration are available, so that long-term average and cumulative concentration of respirable coal dust and quartz component can be derived. The effects of exposure on lung function parameters (FVC, FEV1, FEV1/FVC) were estimated with generalized estimation equation (GEE) models, after adjusting for anthropometric factors, smoking behaviour, and lung function measuring devices.

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