Advances in Leukemia Research and Treatment

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Table of Content: Volume 2, Issue 1

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Brief Communication Pages 28-33

Efficient Ex Vivo Expansion of γδ T-Cells from AML Patients Requires Elimination of Circulating Leukemic Blasts

Authors: Ana C Parente-Pereira, Pramila Krishnamurthy, Lynsey M Whilding, Kyriaki Ioannou, Sara Ciprut, Victoria Potter, Ghulam J Mufti, Linda Barber, Farzin Farzaneh and John Maher

Abstract: γδ T-cells play an important role in immune surveillance of acute myeloid leukemia (AML). The main circulating subtype expresses a Vγ9Vδ2 T-cell receptor and may be expanded ex vivo following aminobisphosphonate activation. While such protocols operate robustly in healthy donors, they are often inefficient using blood samples from patients with advanced malignancy.

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Case Report Pages 25-27

Preserving Platelet Count for a Diagnosed Patient with Acute Myeloid Leukemia on Hydroxychloroquine: A Case Report

Authors: Dina K. Farrag and Nagwa A. Sabri

Abstract: A female patient (N.H.) 70-years-old, married and having two children was admitted to the oncology department El Agouza police Hospital, Egypt on July 2018, She was diagnosed with Relapsed Acute Myeloid Leukemia (AML), with the following clinical presentation; fever, shortness of breath, frequent coughing, night sweats, joint pain and bruising, her ultrasound examination revealed mild splenomegaly, moreover, there was an evidence of endocrinology diagnosis with Type II Diabetes and Grade III Obesity.

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Case Report Pages 23-24

Role of Allogenic Bone Marrow Transplant in Patients with Paroxysmal Nocturnal Haemoglobinuria

Authors: Padmaja Lokireddy and Harshita Mydamn

Abstract: 37-yrs-old male patient presented with jaundice and passing cola colored urine. His blood parameters show Hb-6.5, WBC 6400, platelet count 2.6 lakhs, MCV-115, bilirubin-3.0, LDH-4980, Coombs test- negative, Urine hemosiderin positive. Bone marrow showed marked Erythroid hyperplasia, PNH screen positive of 56% (CD55, CD59).

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