Archives of Immunology

Archives of Immunology

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Table of Content: Volume 2, Issue 1

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Research Article Pages 26-29

Mental Health Issues Related to Some COVID-19 Aspects: Online-Based Bulgarian Survey

Authors: Tsvetelina Velikova, Vasil Jenkov, Stanislav Kotsev, Daniel Georgiev and Hristiana Batselova

Abstract: The mental health of the population is affected during the ongoing COVID-19 pandemic. The goal of our cross-sectional research was to explore some of the mental health dimensions and the attitudes of Bulgarian people during the pandemic through a direct online anonymous individual survey.

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Opinion Pages 24-25

Dysphonia, a Manifestation of a Rare Adverse Effect of Inhaled Corticosteroids

Authors: Miguel Mayo-Yáñez and Irma Cabo-Varela

Abstract: A 76-year-old woman with fluctuating dysphonia, accompanied by heartburn and a need of continuous throat clearing, of a month of evolution. As personal history she presents hypertension, type II diabetes, dyslipidemia and bronchial asthma. Non-smoker or alcohol consumer. The patient did not present fever, the blood analysis showed no alterations and there were no changes in the symptomatology with the corporal posture. She reported worsening during the day and having been treated with Proton- pump inhibitors without improvement.

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Commentary Pages 22-23

QT Interval Prolongation in COVID-19: Hypercytokinaemia is the Forgotten Culprit and Hydroxychloroquine Simply Add Fuel to the Fire

Authors: Sudhir Mehta, Sudhir Bhandari and Shaurya Mehta

Abstract: The prevalence of arrhythmias varies in COVID-19. In a study of 138 patients from Wuhan, who were hospitalized with COVID-19 related pneumonia, arrhythmias were reported in 17% of the general cohort and in 44% of patients admitted to an intensive care unit. A subgroup of patients with severe COVID-19 has a cytokine storm syndrome. Secondary Haemophagocytic lymphohistiocytosis (sHLH) is an under-recognized, hyper-inflammatory syndrome characterized by a fulminant and fatal hypercytokinaemia with multi-organ failure. In adults, sHLH is most commonly triggered by viral infections.

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Opinion Pages 18-21

COVID-19: An Acute Secondary Interferonophaty? The Mirror of Autoinflammatory Syndromes

Authors: Julián Fernández-Martín, Pérez-Álvarez Roberto and Lamas-Barreiro José María

Abstract: Between 1 and 2% of SARS-CoV-2 infected patients develop a devastating acute systemic inflammatory syndrome with predominantly pulmonary expression. Clinical data, analytical findings and the few pathological references we have so far suggest SARS-CoV-2 lung disease could be a secondary interferonopathy with pulmonary alveolar proteinosis (PAP)- like features and sometimes thrombotic microangiopathy.

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Research Article Pages 11-17

Differences in Anti Malarial Antibody Concentrations and Specificities between Male and Female Ugandan Children

Authors: Brenda Apio Okech, Corran P, Todd J, Agwang C, Riley EM and Egwang TG

Abstract: In Uganda malaria poses a formidable burden to an over-stretched and under-funded public health system trying to cope with other pressing health problems like HIV/AIDS and tuberculosis. Our earlier work on asexual blood stage malaria vaccine candidate merozoite surface protein (MSP119) provided a novel means of assessing antibody quality using altered proteins as well as ELISA competition assays with mouse monoclonal antibodies of known specificities.

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