Clinical Hematology and Research

 ISSN: 2689-8896

Clinical Hematology and Research

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Table of Content: Volume 5, Issue 1

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Case Report Pages 74-77

Correlation of SLC19A1 A80G and MTHFR C677T Polymorphisms with Methotrexate-Induced Hepatotoxicity in a Paediatric Acute Lymphoblastic Leukaemia Patient: A Case Report

Authors: Karen Ilenia Álvarez Tosco, MS, María Micaela Viña Romero, MS, Héctor González Méndez, MD, Javier Merino Alonso, PhD, Gloria Julia Nazco Casariego, PhD, Ruth Ramos Díaz, PhD and Fernando Gutiérrez Nicolás, PhD

Abstract: High-dose methotrexate is a crucial component of acute lymphoblastic leukaemia (ALL) treatment regimens. Adherence and tolerance to the treatment plan are critical factors to achieve the prognostic goals, therefore, any signs of toxicity should be taken into consideration. This study describes the clinical case of an ALL paediatric patient who developed hepatotoxicity after methotrexate treatment.

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Research Article Pages 69-73

Significance of Some Markers of Systemic Inflammation and Platelet Activation in Patients with Type 2 Diabetes Mellitus in the Enugu State University of Science and Technology Teaching Hospital Enugu State Nigeria

Authors: Ogbuabor Alphonsus Ogbonna, Onyia Nkiruka Loius and Nwobodo Humphrey Afam

Abstract: Diabetes mellitus has over the years become a public health challenge and a complex disease which is characterized by chronic hyperglycemia that results in microvascular and macro vascular complications. The present study was designed to determine (i) The concentration of markers of platelet activation and (ii) The concentration of markers of systemic inflammation in patients with type 2 diabetes mellitus in Enugu State University of Science and Technology Teaching Hospital. A total of 240 subjects comprising 120 Type 2 Diabetic Mellitus (T2DM) (60 males and 60 females) aged 20-55 years and 120 apparently healthy age and gender-matched controls were recruited for the study.

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Research Article Pages 64-68

Research of Pencil Cells and Precheratocyte in Patients with Microcytic Anemia- Our Experience

Authors: Antonella Mileti, Maria Pepe, Luigia Loiodice, Domenica Leogrande, Vincenzo Brescia, Ersilia Cleopazzo, Michele Pasculli, Francesca Castellaneta, Roberto Lovero, Salvatore Scacco and Francesca Di Serio

Abstract: The most frequent forms of microcytic anemia are: Iron deficiency anemia (IDA), β-thalassemia and chronic disease anemia (ACD) alongside the traditional laboratory parameters (RDW, iron, ferritin, etc.), the evaluation of the peripheral smear, for the search for some cellular elements is also fundamental for a correct diagnosis.

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Case Report Pages 62-63

The Role of Clinical Prediction Scores in Thrombotic Thrombocytopenic Purpura

Authors: Sevoyan A, Chakhoyan A, Ghazaryan P, Ter Grigoryan A, Hakobyan Y, Grigoryan H, Oseyan H and Martirosyan N

Abstract: Thrombotic thrombocytopenic purpura (TTP) is a fulminant and life-threatening blood disorder characterized by a pentad of microangiopathic hemolytic anemia, thrombocytopenia, acute renal failure, fever, neurological abnormalities, and multiple organ ischemias due to disseminated microvascular platelet-rich thrombi. This state is caused by a severe deficiency of ADAMTS13 protein (protease that cleaves von Willebrand factor (VWF) into smaller sizes and thereby eliminates unusually large VWF multimers that would otherwise accumulate on endothelial cells where they can cause platelet thrombi). TTP can be classified as congenital (extremely rare, genetic deficiency of the ADAMTS13 gene resulting in decreased or absent ADAMTS13 enzyme activity) and acquired (presence of an autoantibody against ADAMTS13 enzyme). Diagnosis of TTP is confirmed by the detection ADAMS13 activity, autoantibodies anti ADAMTS13 and screening for ADAMTS13 mutation.

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Case Report Pages 59-61

Failed Reticulocyte Count in a Patient after Cardiac Surgery

Authors: Norbert Ostendorf, MD and Veronika Jennissen, MD

Abstract: The evaluation of erythropoesis by reticulocyte analysis is a mainstay in the diagnosis of anaemia. The classical method comprises staining with brilliant cresyl blue and counting the number of reticulated red blood cells under the microscope. Current hematology analysers perform reticulocyte counting via fluorescence flow cytometry after staining with a dye that adheres to nucleic acid. This has almost completely replaced the manual counting, which is labour intensive. The differentiation between mature erythrocytes and reticulocytes is done automatically by the software.

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