Clinical Diabetes and Research

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Table of Content: Volume 5, Issue 1

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Case Report Pages 63-67

Euglycemic Diabetic Ketoacidosis in a Diabetic Patient Treated with SGLT2 Inhibitor

Authors: Olga Lavrynenko, MD, PhD, Hector Santos, MD, Amando Garza, MD, Rayan Qazi, MD, and Leopoldo Cobos, MD

Abstract: Diabetic ketoacidosis (DKA) is a life - threatening complication and must be diagnosed and treated promptly and aggressively. The classic triad of DKA is: Hyperglycemia (blood glucose (BG) > 250 mg/dl: Anion gap metabolic acidosis (pH < 7.30 and bicarbonate < 18 mEq/L): And ketonemia. With Food and Drug Administration (FDA) approval of the sodium - glucose transporter 2 inhibitors (SGLT2i), DKA can occur with BG levels below 200 mg/dl and has been defined a

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Short Report Pages 62

High Serum Insulin Level in Neonatal Hypoglycemia: A False Expectation

Authors: Shabih Manzar, MD

Abstract: Hyperinsulinemia literally means high serum insulin level (Hyper: Excess, over, beyond, exaggerated). The Pediatric Endocrine Society recommends measuring serum insulin in the evaluation of persistent hypoglycemia in neonates. However, the serum insulin might not be high in cases of hypoglycemia secondary to hyperinsulinism- thus it is a false expectation. The plasma insulin concentration is affected by its pharmacokinetics. A large fraction of the pancreatic insulin is cleared by the liver at first bypass. Therefore, the insulin concentration measured in peripheral plasma may be up to 90% lower than the initial peak concentration

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Research Article Pages 55-61

Disposition Index (DI) is not Improved with High-Intensity Intermittent Exercise in Adults with Hyperinsulinemia and Pre-Diabetes

Authors: Oana Ancu, Jane Naufahu, Richie Barclay, Peter Watt and Richard WA Mackenzie

Abstract: The progression from pre-diabetes to overt type 2 diabetes is largely attributed to β-cell dysfunction and reduced insulin responsiveness. Exercise improves β-cell function in type 2 diabetics, however in pre-diabetic populations there is no data to support a similar response to acute high intensity exercise. Nine individuals diagnosed

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