Chromatography and Spectroscopy Techniques

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Table of Content: Volume 2, Issue 1

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Research Article Pages 21-27

The Influence of UV Irradiation on Diabetic Mice Skin: A Vibrational FT-IR and Raman Spectroscopic Study

Authors: J Anastassopoulou, M Kyriakidou, V Mamareli, O Tanis and M Rallis

Abstract: The aim of this study was to investigate the effect of UV irradiation on streptozotocin-induced diabetic skin. 42 hairless male mice were divided into three groups of control non-diabetic and with dose of streptozotocin 20 and 30 mg/kg. Both FT-IR and Raman spectra showed considerable changes between the diabetic and non-diabetic mice, as well as after irradiation. The most important changes between healthy and diabetic groups were observed in the reduction

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Research Article Pages 12-20

Isolation, Purification and Structural Identification of Degradation Products from Ketoconazole in a Liquid Formulation: An HPLC and HPLC-MS/MS Study

Authors: Fa Zhang, Ph.D

Abstract: Ketoconazole is the active ingredient in an antifungal liquid formulation for topical application. A binary gradient HPLC analysis indicated that ketoconazole in the formulation produced four degradation products at minor levels after storage at room temperature for about 3 years. These degradation products were isolated and purified using semi-preparative HPLC procedures followed by analysis using off-line HPLC-ESI-MS and HPLC-ESI-MS/MS.

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