Current Trends in Analytical and Bioanalytical Chemistry

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Table of Content: Volume 5, Issue 1

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Original Article Pages 158-166

Paclitaxel-Copper Composite: A Metallodrug Model System Enroute Ultrasonic Force

Authors: Amol A Shedge, Shubham V Pansare, Dnyaneshwar K Kulal, Shyam R Khairkar, Shraddha Y Chhatre, Debiprasad Panda, Maryappa C. Sonawale, S Chakrabarti, Amol V Pansare and Vishwanath R Patil

Abstract: Paclitaxel (PTX), an anti-microtubule agent, widely used as an efficacious anti-neoplastic drug in the treatment of numerous cancer diseases. The major disadvantage of PTX drug is practical insolubility in aqueous media and poor bioavailability, which directly impacts drug absorption in human beings. In this research, we successively tried to increase the bioavailability of PTX, by synthesizing PTX-Copper nanocomposite (Cu NCP) using water bath type ultrasonication

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Research Article Pages 150-157

Stability-Indicating HPLC-DAD Determination of Lamivudine in Pharmaceutical Preparations and Biological Fluids

Authors: Rim S Haggag, Saied F Belal, Ismail I Hewala and Ola A El Rouby

Abstract: A simple, selective, and stability-indicating high pressure liquid chromatographic method with diode array detection was developed for the analysis of lamivudine in tablets. The separation was performed on a C18 (octylsilyl) BDS Hypersil®column (4.6 × 150 mm × 5 μm), with isocratic elution of the mobile phase composed of acetonitrile and 50 mM phosphate buffer of pH 4 (adjusted using phosphoric acid) in a ratio of (10:90) v/v.

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