Alzheimers Disease & Dementia

Review Article Pages 140-144

Role of Extracellular Matrix Stiffness Inhibitors in Alzheimer's Disease

Authors: Garry Kerch

Abstract: Alzheimer’s disease is closely related with ageing and age-related extracellular matrix stiffness increase. The association between stiffness and NF-kB activation was demonstrated and link between tissue stiffness and inflammation was suggested. The inhibitors of extracellular matrix stiffening have been reviewed as potential drug components for Alzheimer’s disease retardation, prevention and treatment.

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