Alzheimers Disease & Dementia

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Table of Content: Volume 5, Issue 1

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Research Article Pages 126-131

Photobiomodulation Improves Memory in Mild Cognitive Impairment: Three Case Reports

Authors: Agnes S Chan, TszLok Lee, Sophia Sze and Michael R Hamblin

Abstract: Three patients (mean age = 62) received 18-sessions of PBM stimulation twice per week for nine weeks. Each patient was assessed with Rey- Osterrieth Complex Figure Test (Rey-O testing visual memory) and Hong Kong List Learning Test (HKLLT testing verbal memory), Clinical Dementia Rating Scale (CDR), Functional Activities Questionnaire (FAQ), Geriatric Anxiety Scale-10 Item Version (GAS-10) and Chinese Geriatric Depression Scale (CGDS) before and after PBM.

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Research Article Pages 113-118

Drug Nanotargeting for Treating Vascular Dementia and Alzheimer's Disease

Authors: Joseph S. D'Arrigo, PhD

Abstract: Microvascular endothelial dysfunction precedes, often by decades, the cognitive decline associated with Alzheimer's disease. Hence, preservation of a healthy cerebrovascular endothelium can be an important therapeutic target. By incorporating appropriate drug(s) into biobased (lipid cubic phase) nanocarriers, one obtains a multitasking combination therapeutic which targets certain cell-surface scavenger receptors, mainly class B type I (i.e., SR-BI), and crosses the blood-brain barrier.

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