Table 1: Limitations of CDC-XM [49].
| Limitations of CDC-XM |
|---|
| Requires a constant supply of fresh viable donor lymphocytes |
| Testing process is cumbersome especially in the emergency setting for deceased donor transplants |
| Low sensitivity with false negative results; caused by low titre DSA, complement inactivation, etc. |
| Low specificity with false positive results due to autoantibodies, immune complexes, etc. |
| Non-complement fixing antibodies are not detected |
| Lack of standardization regarding panel composition among different laboratories |