Table 1: Striatal levels of dopamine (DA) and DOPAC (ng/g tisuue).
| Experimental group | Dopamine | DOPAC |
| 6-OHDA ipsilateral |
447.8 ± 79.63a | 752.3 ± 201.1 |
| 6-OHDA contralateral |
2027 ± 337.3 | 713.9 ± 16.63 |
| SEMU 10 ipsilateral |
1146 ± 185.4 | 990.3 ± 417.4 |
| SEMU 10 contralateral |
1994 ± 30.67 | 333.8 ± 46.78 |
| SEMU 20 ipsilateral |
1913 ± 146.2 | 2003 ± 318.6a,b |
| SEMU 20 contralateral |
2072 ± 588.3b | 304.7 ± 46.55 |
| SEMU 40 ipsilateral |
2450 ± 163.7a,b | 687.8 ± 373.1a |
| SEMU 40 contralateral |
3921 ± 221.8 | 1755 ± 172.1 |
| SO ipsilateral |
2668 ± 350.4b | 1985 ± 182.4b |
| SO Contralateral |
2986 ± 519.3 | 774.0 ± 68.83 |
Myracrodruon urundeuva Hydroalcoholic Extract (SEMU 10, SEMU 20 and SEMU 40 mg/kg, p.o) was administered daily for 14 days. The treatment started 30 min before and 1 hour after the unilateral 6-OHDA stereotaxic injection. Two weeks after the stereotaxic procedure, the animals were sacrificed by decaptation to remove both the right and left striata. The results were expressed as mean ± SEM. Ipsilateral is the striatum of the side where 6-OHDA was injected (right lesioned-side) and contralateral is the striatum opposite to the lesion (left side).
6-OHDA group: Lesioned without treatment; SO group: Sham operated animals.
ap < 0.05 vs. contralateral control of the same group, bp < 0.05 vs. 6-OHDA group (ipsilateral to injury) (ANOVA and Student-Newman-Keuls test).
6-OHDA: 6-hydroxydopamine; SO: Sham operated.