Table 5: Stability of BZP and TFMPP in derivatized plasma, urine and cell culture medium.
_____ |
Concentration (µg/mL) |
Derivatized plasma sample stability (CV%) |
Derivatized urine sample stability (CV%) |
Derivatized cell culture medium sample stability (CV%) |
|||
BZP |
TFMPP |
BZP |
TFMPP |
BZP |
TFMPP |
||
Day 1 |
0.016 |
8 |
4 |
6 |
2 |
- |
- |
0.4 |
0 |
7 |
7 |
6 |
- |
- |
|
0.625 |
- |
- |
- |
- |
4 |
7 |
|
2.5 |
- |
- |
- |
- |
2 |
1 |
|
10 |
2 |
3 |
7 |
7 |
2 |
1 |
|
Day 2 |
0.016 |
18 |
9 |
13 |
14 |
- |
- |
0.4 |
3 |
4 |
15 |
15 |
- |
- |
|
0.625 |
- |
- |
- |
- |
3 |
2 |
|
2.5 |
- |
- |
- |
- |
5 |
7 |
|
10 |
5 |
3 |
14 |
15 |
1 |
2 |
|
Day 3 |
0.016 |
61 |
54 |
93 |
72 |
- |
- |
0.4 |
12 |
2 |
28 |
26 |
- |
- |
|
0.625 |
- |
- |
- |
- |
0 |
1 |
|
2.5 |
- |
- |
- |
- |
3 |
9 |
|
10 |
9 |
6 |
24 |
27 |
8 |
4 |
|
Day 4 |
0.016 |
126 |
134 |
92 |
117 |
- |
- |
0.4 |
22 |
18 |
54 |
53 |
- |
- |
|
0.625 |
- |
- |
- |
- |
4 |
8 |
|
2.5 |
- |
- |
- |
- |
1 |
3 |
|
10 |
11 |
8 |
52 |
72 |
0 |
3 |
|
Day 5 |
0.016 |
139 |
139 |
- |
- |
- |
- |
0.4 |
43 |
39 |
- |
- |
- |
- |
|
0.625 |
- |
- |
- |
- |
12 |
15 |
|
2.5 |
- |
- |
- |
- |
1 |
9 |
|
10 |
17 |
15 |
- |
- |
2 |
0 |