Author/Year

Type of study

Sample

(n = patients)

Findings

Dean, et al. [12]

Randomized, double-blind, placebo-controlled clinical study

98

No benefits observed

Çelebi Fahri, et al. [21]

Case report

8

Improvement of repetitive behaviors

Ghanizadeh, et al. [22]

Case report

40

Reduction in irritability

Ghanizadeh, et al. [17]

Randomized, double-blind, placebo-controlled clinical study

40

The association of risperidone with NAC reduced irritability

Hardan, et al. [20]

Randomized, double-blind, placebo-controlled clinical study

33

Significant reduction in irritability; Decrease in repetitive behaviors

Marler, et al. [24]

Case report

1

Reduction of self-injurious behavior

Nikoo, et al. [19]

Randomized, double-blind, placebo-controlled clinical study

40

Reduction in irritability

Önder, et al. [25]

Case report

6

Reduction of irritability and aggressiveness

Pesko, et al. [18]

Case report

4

Reduction in irritability

Wink, et al. [16]

Randomized, double-blind, placebo-controlled clinical study

32

Increased levels of GSH in peripheral blood