Table 2: Summary of non-clinical literature searches on FCAs and behavior1
| FD & C Color Name | Synonyms | Date of EFSA Opinion adoption | # of records returned | # of full-length articles reviewed | # of relevant unique records |
| FD & C Blue No. 1 | Brilliant Blue FCF CI Blue 2 INS 133 CAS RN 3844-45-9 |
07-Oct-10 | 229 | 7 | 4 |
| FD & C Blue No. 2 | Indigo Carmine/Indigotine CI Blue 1 INS 132 CAS RN 860-22-0 |
04-Jul-14 | 104 | 1 | 0 |
| FD & C Red No. 3 | Erythrosine INS 127 CAS RN 16423-68-0 |
07-Oct-10 | 18 | 2 | 1, 1* |
| FD & C Red No. 40 | Allura Red AC CI Red 17 INS 129 CAS RN 25956-17-6 |
23-Sep-09 | 124 | 5 | 1, 2** |
| FD & C Yellow No. 5 | Tartrazine CI Yellow 4 INS 102 CAS RN 1934-21-0 |
23-Sep-09 | 36 | 7 | 5 |
| FD & C Yellow No. 6 | Sunset Yellow FCF CI Yellow 3 INS 110 CAS RN 2783-94-0 |
24-Sep-09 | 25 | 4 | 0 |
| FD & C Green No. 3 | Fast Green FCF CI Food Green 3 INS 143 CAS RN 2353-45-9 |
N/A2 | 23 | 2 | 1 |
1Each literature search was performed using the following formula: ((FD & C Color name or Synonyms) AND (neurobehavioral or neurotoxicity or non-clinical study or brain or nervous or learning or memory or cerebral) using a date range from the date of EFSA Opinion Adoption to 26 July 2019 (i.e. date the searches were performed).
2No date filter was used for this literature search because EFSA has not published an Scientific Opinion on this color and JECFA’s full safety monograph (FAS) is not available at the time of this writing.
*An additional publication [53] was identified via a reference in JECFA [55].
**An additional two publications [54,77] were identified via a reference in Noorafshan, et al. [55].