Table 1: Demographic and histopathologic features of all needle core biopsies.
IgG4RD | PBC | PSC | AIH | HCV | Unknown etiology | |
---|---|---|---|---|---|---|
Total no. of cases | 3 | 19 | 18 | 22 | 25 | 1 |
Age at biopsy (years, avg/range) | 51/32-62 | 53/30-74 | 36/11-61 | 43/7-73 | 48/23-67 | 53 |
Male:Female | 2:1 | 1:18 | 7:11 | 9:13 | 14:11 | 1:0 |
No. positive ANA titer cases/no. cases performed1 | 1/1 (100%) | 11/16 (69%) | 9/14 (64%) | 21/22 (95%) | 3/3 (100%) | N/A |
No. positive ASMA titer cases/no. cases performed1 | 0/1 (0%) | 0/10 (0%) | 0/10 (0%) | 17/19 (89%) | 0/2 (0%) | 0/1 (0%) |
No. positive AMA titer cases/no. cases performed1 | N/A | 17/19 (89%) | 0/6 (0%) | 1/13 (8%) | 0/1 (0%) | 0/1 (0%) |
AST (avg; U/L) | 136.7 | 73.3 | 112.9 | 405.5 | 49.8 | 80.0 |
ALT (avg; U/L) | 125.0 | 95.2 | 144.8 | 457.5 | 60.2 | 62.0 |
Alkaline phosphatase (avg; U/L) | 516.0 | 258.4 | 519.3 | 189.0 | 89.6 | 143.0 |
Total bilirubin (avg; mg/dL) | 3.9 | 0.8 | 1.5 | 4.7 | 0.5 | 6.0 |
Serum IgG concentration (avg/range)2 | 2587/1420-4730 | 1256/1030-1510 | 1432/845-2360 | 3323/1240-6060 | N/A | N/A |
Serum IgG4 concentration (avg/range)3 | 65/14.2-125 | N/A | N/A | N/A | N/A | N/A |
Clinical history of pancreatitis | 1 (33%) | N/A | N/A | N/A | N/A | N/A |
Plasma cells/5 HPF (avg/range) | 269/140-376 | 73/5-289 | 10/0-38 | 131/19-345 | 16/2-44 | 48 |
IgG4+ plasma cells/5 HPF (avg/range) | 101/80-127 | 0.3/0-2 | 0.4/0-6 | 8/0-29 | 0.5/0-3 | 24 |
IgG4+ plasma cells:total plasma cells (%) | 43%/27-69% | 1%/0-7% | 0.2%/0-16% | 5%/0-16% | 6%/0-50% | 52% |
Eosinophils/5 HPF (avg/range) | 51/7-130 | 23/5-120 | 3/0-11 | 13/1-29 | 12/1-28 | 55 |
1ANA, AMA, AMSA considered positive if titer ≥ 1:160; 2Reference range of serum IgG concentration 588-1573 mg/dL; 3Reference range of serum IgG4 concentration 2.4-121.0 mg/dL.
AIH: Autoimmune Hepatitis; ALT: Alanine Transaminase; AMA: Anti-Mitochondrial Antibody; ANA: Anti-Nuclear Antibody; ASMA: Anti-Smooth Muscle Antibody; AST: Aspartate Transaminase; GGT: Gamma-Glutamyl Transferase; HCV: Chronic Hepatitis C; HPF: High Power Field; IgG: Immunoglobulin G; PBC: Primary Biliary Cirrhosis; PSC: Primary Sclerosing Cholangitis.