Factor

Overall Survival

Recurrence Free Survival

HR (95% CI)

P value

HR (95% CI)

P value

Age > 60

NS

NS

Gender

NS

NS

Age Adjusted Comorbidity Index (≤ 4 vs > 4)

3.68 (1.37 – 9.84)

0.0003

NS

AJCC 7 stage 

NS

NS

AJCC 8 stage 

Stage I – Ref

0.0001

Stage I – Ref

<0.0001

Stage II – 4.58 (2.02 - 10.42)

Stage II – 7.73 (3.16 – 18.90)

Stage III – 8.72 (2.42 - 31.47)

Stage III – 14.60 (3.45 – 62.10)

pT stage (7th edition)

pT1 – Ref

0.006

pT1 – Ref

0.002

pT2 – 3.20 (1.28 – 8.00)

PT2 – 1.23 (0.46 – 3.27)

pT3 – 7.57 (2.5 – 23.00)

pT3 – 6.16 (1.83 – 20.65)

pT4a – 9.22 (2.24 – 37.95)

pT4a – 3.66 (0.74 – 18.11)

pT4b – 5.21 (0.25 – 106.90)

pT stage (8th edition)

pT1 – Ref

0.007

pT1 – Ref

0.0008

pT2 – 3.20 (1.28 – 8.00)

pT2 – 1.23 (0.46 – 3.27)

pT3 – 7.57 (2.50 – 23.00)

pT3 – 6.15 (1.83 – 20.65)

pT4 – 7.76 (2.06 – 29.30)

pT4 – 3.95 (0.90 – 17.28)

pN stage (7th edition)

NS

NS

pN stage (8th edition)

pN0 – Ref

0.003

pN0- Ref

0.006

pN1 – 3.54 (1.48 – 8.50)

pN1 – 0.63 (0.08 – 4.59)

pN2 – 2.95 (0.46 – 19.00)

pN2 – 2.27 (0.28 – 18.40)

Margin Status

NS

3.10 (0.89 – 10.73)

0.008

PNI

2.87(1.19 – 6.90)

0.004

3.04 (1.15 – 7.99)

0.005

LVI

NS

2.85 (1.21 – 6.69)

0.01

ECE

2.80 (1.27 – 6.22)

0.006

2.48 (1.05 – 5.87)

0.02

Grade

NS

NS

Smoking Status (never vs former vs current)

NS

NS

Smoking 10 pack years

NS

NS

Smoking 20 pack years

3.20 (1.49 – 7.02)

0.002

2.55 (1.10 – 5.91)

0.02

Time from diagnosis to treatment (> 60 days vs < 60 days)

NS

NS

Adjuvant Management

NS

NS

Concurrent chemotherapy schedule

NS

NS

Time to adjuvant management (> 6 weeks vs < 6 weeks)

NS

NS