Table 1: Summary of HPV gene functions [10].
Gene Product |
Function |
Activities |
E1 |
Replication of viral genome |
DNA-binding activity, helicase
activity, ATPase |
E2 |
Transcription of viral genes Replication and maintenance of viral
genome |
Transactivation/Transrepression,
DNA-binding activity, DNA segregation in mitotic cell |
E4 |
Unknown |
Destruction of keratin network,
induction of G2M arrest of cell cycle |
E5 |
Possibly involved in proliferation
and/or inhibition of apoptosis |
Affection of cellular signaling pathway |
E6 |
Reactivation of cellular replication
mechanisms Proliferation, immortalization,
inhibition of apoptosis Maintenance of viral genome |
Interactions with various cellular
proteins |
E7 |
Reactivation of cellular replication
mechanisms Proliferation, genomic instability,
inhibition of apoptosis Maintenance of viral genome |
Interactions with various cellular
proteins |
L1 |
Major capsid protein |
|
L2 |
Minor capsid protein |
|