Table 1: List of examined products and their information. Note that the product numbers mentioned in the table correspond to their numbers mentioned in the test report. Product 5 was omitted, and Product 6 was excluded due to unclear images.

Product number

Product name

HA source

Indication and mode of application

Tissue of application

HA type and concentration

Manufacturer

1

Lancs hyaluronic Acid H+ Serum

Bacterial origin

Nourishing the skin

Topical application on face skin

HA, Propylene Glycol, Glycerine, Acrylic acid copolymer, Alpinia Galanga, Viola tricolour, Carbomer, triethanolamine, Aloe barbadensis.

Lancs

2

Asterwood Natural

Hyaluronic acid Serum

Bacterial origin

Nourishing the skin

Topical application on face skin

HA, Phenoxyethanol less than 2%, Benzoic Acid, Dehydroacetic Acid.

Asterwood Naturals

3

Concentrated Natural

Hyaluronic Acid 100% Serum

Unknown

Nourishing the skin

Topical application on face skin

Unknown

Concentrated naturals

4

Vitamin C Serum with HA 20%

Bacterial origin

Nourishing the skin

Topical application on face skin

20% HA, Vitamin C, Vitamin E, Green Tea.

Passport to Organics, USA

7

Ostenil® Plus 2 ml

Bacterial origin

Injectable HA for reduction of pain and improved functionality of osteoarthritic joints.

Knee capsule and other articular joints.

20 mg/ml linear sodium hyaluronate + 5 mg/ml mannitol.

TRB Chemedica AG, Germany.

8

Hyabell® Deep

Bacterial origin

Injectable HA face filler

Deep face depressions (excluding areas with limited soft tissue support or cover (e.g., forehead, periorbital area).

Cross-linked HA 20 mg/ml + Lidocaine hydrochloride 3 mg

Adoderm GmbH, Germany

9

CRM Vurdex®

Bacterial origin

Injectable HA for VUR treatment

Ureter tissue

Cross-linked HA 10 mg/ml + Dextranomere 20 mg/ml

BioScience GmbH, Germany.

10

Crespine®

Gel 2 ml

Bacterial origin

Injectable HA for reduction of pain and improved functionality of osteoarthritic joints.

Knee, Hip capsule

Linear HA 1.0 mg/ml + Cross-linked HA 14.0 mg/ml

 

Biopolymer GmbH, Germany.

11

Crespine®

Gel Plus 2 ml

Bacterial origin

Injectable HA for reduction of pain and improved functionality of osteoarthritic joints.

Knee, Hip capsule

Linear HA 1.0 mg/ml +

Cross-linked HA 14.0 mg/ml + Prilocaine hydrochloride 3.0 mg/ml

Biopolymer GmbH, Germany.

12

Teosyal®

RHA4

Bacterial origin

Injectable HA face filler

To correct moderate to severe wrinkles and nasolabial folds.

Cross-linked HA 23.0 mg/ml + lidocaine hydrochloride 3 mg/ml

Teoxane SA, Geneve, Switzerland.

13

Teosyal® Pure Sense Ultra Deep

Bacterial origin

Injectable HA face filler

To correct deep wrinkles (cheek and upper cheek augmentation and redefining the contours of the face.

Cross-linked HA 25 mg/ml + lidocaine chlorhydrate

Teoxane SA, Geneve, Switzerland.

14

Synocrome® 2 ml

Bacterial origin

Injectable HA for reduction of pain and improved functionality of osteoarthritic joints.

Knee, Hip, Shoulder, Ankle capsule

10 mg/ml linear sodium hyaluronate + citric acid.

Chroma-Pharma, Austria

15

Hyadent® BG

Bacterial origin

Injectable HA for soft and hard tissue regeneration and as a gel scaffold

Oral gingiva

Linear HA 2.0 mg/ml + Cross-linked HA 16.0 mg/ml

BioScience GmbH, Germany.

16

Maxface Soft

Bacterial origin

Injectable HA face filler

Upper to mid dermis to correct light to medium wrinkles (Mariotte lines, nasolabial folds)

Linear HA 3 mg/ml + Cross-linked HA 21 mg/ml

Naturelize GmbH, Germany.

17

Maxface

Bacterial origin

Injectable HA face filler

Mid to low dermis to correct medium to deep wrinkles and for volume augmentation.

Cross-linked HA 24 mg/ml

Naturelize GmbH, Germany.

18

Monovisc® 4 ml

Bacterial origin

Injectable HA for reduction of pain and improved functionality of osteoarthritic joints.

Knee capsule

Cross-linked HA 22 mg/ml

Anika Therapeutics®S.R.L, Italy.

19

Inline

Bacterial origin

Injectable HA face filler

Upper to mid dermis to correct light to medium wrinkles and light lip augmentation.

Cross-linked HA 16 mg/ml

Naturelize GmbH, Germany.

20

Inline Soft

Bacterial origin

Injectable HA face filler

Upper to mid dermis to correct light wrinkles.

Cross-linked HA 16 mg/ml

Naturelize GmbH, Germany.

21

Suplasyn® 1-shot 6 ml

Bacterial origin

Injectable HA for reduction of pain and improved functionality of osteoarthritic joints.

Knee capsule

Liner HA 10 mg/ml

Mylan Pharma Group Limited, Ireland.