Details of the considered molecule and dose and of the numerical approaches considered in 3D physiological models of drug delivery to the PSE.

Table 3: Details of the considered molecule and dose and of the numerical approaches considered in 3D physiological models of drug delivery to the PSE.

Reference	Molecule	Drug dosage/source	Numerical approach	Estimated coefficients
[16]	Gd-DTPA (0.96 kDa hydrophilic)	from in vitro release curves	FEMs (FEMLab)	diffusion coefficient in the posterior membrane fitted from in vivo models and MRI data
[21]	fluoroscein, range of low-to-high weight molecules	IV bolus injection: initial uniform concentration of drug throughout the hemi-spherical injection volume; implant: prescribed delivery rate	FEMs
[18]	fluorescent protein (GFP)	prescribed constant drug concentration in the epiocular space	finite differences	molucule diffusivities in sclera computed from Stokes-Einstein eq.; molecule diffusivities in the other layers estimated from scleral diffusivity and relative extracellular fractions
[13]	fluoroscein	prescribed constant concentration at the sclera surface	FEMs	mass transfer coefficient at the scleral surface and choriocapillary clearance rate from best fit between model predicted concentration of the vitreous and experiments
[15]	fluoroscein, sucrose	prescribed initial drug concentration in the spherical injected bolus; different positions for injection	finite volumes (FLUENT)	hydraulic resistance of the trabecular meshwork adjusted until the desired IOP is obtained; diffusivities for the dextran polymers calculated via Stokes-Einstein equation
[14]	anecortave acetate (0.39 kDa)	exponential decay of drug concentration located in the episcleral depot point	finite volumes (FLUENT)	surface porosity of the sclera from TEM images
[17]	fluoroscein, IgG1 Fab(49 KDa, anti-VEGF)	prescribed exponential decay at the sclera boundary	FEMs	sensitivity study on the mass transfer coefficient of igG1 Fab at the sclera external boundary
[19]	1 kDa unspecified drug	prescribed drug initial condition in the patch	FEMs (COMSOL)	as in [13]
[12]	fluoroscein	systemic: given drug concentration in the choriocapillaries; IV inj: given drug concentration in the bolus	FEMs (COMSOL)
[20]	low-weigth molecule	prescribed exponential decay	FEMs
[22]	small molecules (dexamethasone)	drug release from an implant located into the vitreous modeled via a diffusion equation for drug concentration and molecular weight	FEMs (COMSOL)