Table 2: Biophysical phenomena represented in 3D physiological models of drug delivery to the PSE.
Reference | Drug diffusion | Drug convection | Drug clearance | Drug metabolism/binding | RPE pumping | Flow filtration |
[16] | all structures | all structures | none | absent | absent | Darcy in vitreous and posterior membrane |
[21] | all structures | all structures | none | absent | implicit in permeability | NS in vitreous and aqueous |
[18] | all structures | neglected (convection rate at least 20-fold lower than the rate of diffusion) | reaction term in choroid | reaction term (only in periocular tissue and choroid) | absent | none |
[13] | all structures | all structures | clearance from choroid | absent | fictitious convection in retina | Darcy in all layers |
[15] | all structures | all structures | parametric study on clearance from the ASE | absent | absent | NS in aqueous, Darcy elsewhere |
[4] | all structures | only in choroid | Periocular clearance modeled as decaying coefficient in the source | absent | absent | Darcy-Brinkman in all layers |
[17] | sclera, choroid, retina, vitreous | vitreous (neglected elsewhere) | clearance from choroid | loss/degradation in retina and choroid | fictitious convection in retina | Darcy in all layers |
[19] | all structures | only in choroid | none | absent | kinetic flux eq. retina/choroid | NS in choroid |
[12] | all structures | all structures | clearance from choroid | absent | fictitious convection in retina | Darcy in all layers |
[20] | all structures | all structures | clearance from choroid and retinal vessel | reaction term | fictitious convection in retina | Darcy in all layers |
[22] | all structures | all structures | choroid as perfect sink (boundary condition) | absent | permeability coefficient at the retina/choroid boundary | Darcy in all structures |