Table 2: Biophysical phenomena represented in 3D physiological models of drug delivery to the PSE.

Reference Drug diffusion Drug convection Drug clearance Drug metabolism/binding RPE pumping Flow filtration
[16] all structures all structures none absent absent Darcy in vitreous and posterior membrane
[21] all structures all structures none absent implicit in permeability NS in vitreous and aqueous
[18] all structures neglected (convection rate at least 20-fold lower than the rate of diffusion) reaction term in choroid reaction term (only in periocular tissue and choroid) absent none
[13] all structures all structures clearance from choroid absent fictitious convection in retina Darcy in all layers
[15] all structures all structures parametric study on clearance from the ASE absent absent NS in aqueous, Darcy elsewhere
[4] all structures only in choroid Periocular clearance modeled as decaying coefficient in the source absent absent Darcy-Brinkman in all layers
[17] sclera, choroid, retina, vitreous vitreous (neglected elsewhere) clearance from choroid loss/degradation in retina and choroid fictitious convection in retina Darcy in all layers
[19] all structures only in choroid none absent kinetic flux eq. retina/choroid NS in choroid
[12] all structures all structures clearance from choroid absent fictitious convection in retina Darcy in all layers
[20] all structures all structures clearance from choroid and retinal vessel reaction term fictitious convection in retina Darcy in all layers
[22] all structures all structures choroid as perfect sink (boundary condition) absent permeability coefficient at the retina/choroid boundary Darcy in all structures