AD

PD

Dementia

·         Both sirtuin and REST signaling pathways are disturbed both the diseases, AD, PD [37].

·         Affected neurons display intracellular tau-positive inclusions that are distinct from the neurofibrillary tangles observed in AD [39].

·         Lewy bodies, protein aggregation and α-synuclein in PD are also found in > 60% of AD cases [38].

·         The first FTD mutations were identified in cases accompanied by Parkinsonism and showing genetic linkage to chromosome 17q21, near the tau gene (FTDP-17) [24]

·         AD cases have tau tangles.

·         tau aggregation is shown in ~50% of PD cases snRNP70 may co-localize in PD cases [40].

·         Subsequently, disease-causing mutations were identified in tau (gene: MAPT) [22].